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PRMT1-rich exosomes derived from M2 macrophages as novel therapeutics for enhancing fracture healing.
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ID: paper-41610641
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PRMT1-rich exosomes derived from M2 macrophages as novel therapeutics for enhancing fracture healing.
["Hong H", "Zhou C", "Wang H", "Lin C", "Fang M", "Liu J", "Yang M"]
Abstract
PURPOSE: sM2 macrophage-derived exosomes (M2-Exo) have emerged as promising mediators of bone repair due to their anti-inflammatory and pro-regenerative properties. However, the molecular mechanisms underlying the interaction between M2-Exo and bone marrow mesenchymal stem cells (BMSCs) are awaiting clarification. Our previous study found that protein arginine methyltransferase 1 (PRMT1) in fracture-derived exosomes promotes bone healing. This study aimed to determine whether PRMT1-containing M2...
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