Arginine Methylation Enhancement Therapy

## Molecular Mechanism and Rationale The TAR DNA-binding protein 43 (TDP-43) has emerged as a central pathological player in numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and chronic traumatic encephalopathy (CTE). Under physiological conditions, TDP-43 functions as a critical RNA-binding protein that regulates splicing, transcription, and RNA metabolism. However, in disease states, TDP-43 undergoes pathological aggregation an...