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Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Proteinopathy.
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📄 Paper Details
Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Proteinopathy.
Jamerlan A, Hulme J
Abstract
The cytoplasmic accumulation of TDP-43 aggregates remains a persistent pathological hallmark of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43 encephalopathy (LATE). The cell's natural clearance mechanisms, the Ubiquitin-Proteasome System (UPS) and the autophagy-lysosome pathway (ALP), are hypothesized to fail, at least in part, due to the sequestration of key components of these pathways by path...
▸Metadata
| doi | 10.3390/molecules31060924 |
| pmid | 41900026 |
| year | 2026 |
| pmc_id | None |
| _origin | {'url': 'https://pubmed.ncbi.nlm.nih.gov/41900026/', 'type': 'external', 'tracked_at': '2026-04-23T20:17:18.055116'} |
| authors | ['Jamerlan A', 'Hulme J'] |
| journal | Molecules (Basel, Switzerland) |
| _schema_version | 1 |
| quality_status_rationale | {'signals': {'origin_type': 'external', 'quality_score': 0.9, 'lifecycle_state': 'active', 'provenance_chain_length': 0}, 'task_id': 'e98f5d97-9571-43ec-928c-425270079951', 'timestamp': '2026-04-27T01 |
📊 Evidence Profile
Evidence Balance
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Certainty
10%
Debates
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Incoming
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Outgoing
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