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Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.
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ID: paper-41928257
📄 Paper Details
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.
Jeong Y, Cho Y, Kim YK
Abstract
Protein arginine methyltransferases (PRMTs) catalyze the methylation of arginine residues on both histone and non-histone substrates, orchestrating cellular processes such as transcriptional regulation, RNA splicing, signal transduction, and DNA damage response. Because dysregulated methylation reprograms epigenetic and post-transcriptional landscapes to promote malignant transformation, aberrant PRMT activity is closely associated with tumorigenesis and cancer progression. Major family members,...
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