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Fig. 1: LPS causes pervasive BBB leakage and inflammatory responses in brain endothelium...
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Created: 2026-04-16T11:31:41
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ID: paper-fig-39427196-1
Fig. 1Figure 1
LPS causes pervasive BBB leakage and inflammatory responses in brain endothelium and parenchyma. A , Schematic illustration of experimental design. Endotoxemia was induced by LPS injection in male C57BL/6J wild-type (WT) mice. B , Mortality rate of mice at 24 h following saline ( n = 10 mice) or LPS ( n = 14 mice) treatment. C , Body weight change of the mice at 24 h after saline ( n = 6 mice) or LPS ( n = 8 mice) injection. D , Representative brain images showing Evans Blue leakage induced by LPS and its quantifications, presented as nanogram dye per gram brain weight (ng/g). E , Co-immunofluorescence staining of mouse plasma IgG and CD31 in the brain cortex and its quantifications. F , Co-immunofluorescence staining of NF-κB p65 and CD31 in the brain cortex and its quantifications. NF-κB p65 signal in endothelial cells was selectively quantified. G , Co-immunofluorescence staining of VCAM1 and CD31 in the brain cortex and its quantifications. H , Co-immunofluorescence sta
▸Metadata
| doi | |
| pmcid | PMC11491032 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig1_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-16T11:31:41.864388'} |
| caption | LPS causes pervasive BBB leakage and inflammatory responses in brain endothelium and parenchyma. A , Schematic illustration of experimental design. Endotoxemia was induced by LPS injection in male C5 |
| paper_id | 39427196 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig1_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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