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Fig. 2: LPS and proinflammatory cytokines suppress brain endothelial Wnt/β-catenin signa...
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Created: 2026-04-16T11:31:41
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ID: paper-fig-39427196-2
Fig. 2Figure 2
LPS and proinflammatory cytokines suppress brain endothelial Wnt/β-catenin signaling. A-B , Co-immunofluorescence staining of active β-catenin (non-phosphorylated) and CD31 in the brain cortex tissue of mice treated with LPS or saline ( A ) and its quantifications ( B ). Active β-catenin signal in endothelial cells was selectively quantified. n = 6 mice per group. ( C-D ) Co-immunofluorescence staining of LEF1 and CD31 in the brain cortex tissue of mice treated with LPS or saline ( C ) and its quantifications ( D ). n = 6 mice per group. E , RT-qPCR analysis of the expression levels of Wnt/β-catenin signaling target genes Axin2 , Apcdd1 , Nkd1 , and Notum in brain endothelial cells (ECs) isolated by flow cytometry from saline or LPS-treated mice (normalized to β-actin). n = 7 mice per group. F-H , RT-qPCR analysis of the expression levels of Axin2 in mouse brain microvascular ECs (bEnd.3) treated with recombinant Wnt3a protein (100 ng/ml) or Wnt3a protein plus LPS ( F )
▸Metadata
| doi | |
| pmcid | PMC11491032 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig2_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-16T11:31:41.884779'} |
| caption | LPS and proinflammatory cytokines suppress brain endothelial Wnt/β-catenin signaling. A-B , Co-immunofluorescence staining of active β-catenin (non-phosphorylated) and CD31 in the brain cortex tissue |
| paper_id | 39427196 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11491032/bin/12974_2024_3261_Fig2_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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Debates
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Outgoing
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