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Fig. 7: Cardiac-specific PDE4D-knockdown activates mitophagy and protects against TAC-in...
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Fig. 7Figure 8
Cardiac-specific PDE4D-knockdown activates mitophagy and protects against TAC-induced cardiac hypertrophy and heart failure . A, 30 days after TAC or sham surgery, αMHC-Cre+/PDE4D-flox/+ mice were subjected to a single intraperitoneal injection of tamoxifen (100 mg/kg/day) for 5 consecutive days to induce PDE4D ablation in the heart (PDE4D hCKO ). Littermate PDE4D-WT with the same dose of tamoxifen as controls. The mice were sacrificed 12 days after tamoxifen injection. B and C, Ejection fraction ( B ) and fractional shortening ( C ) were measured by echocardiography at 6 weeks after TAC; n = 8 mice per group. D, Cardiac cross-sections were stained with hematoxylin-eosin or WGA to examine heart morphology and measure myocyte CSA; n = 100 cells per heart and n = 3 mice per group. Scale bar, 50 μm. The myocardial apoptosis was detected by TUNEL staining, 2 random fields per heart; n = 3 mice per group. Scale bar, 50 μm. ROS levels were determined by DHE fluorescence intensity in t
▸Metadata
| doi | 10.1016/j.redox.2025.103563 |
| pmcid | PMC11909752 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr7.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:31.442862'} |
| caption | Cardiac-specific PDE4D-knockdown activates mitophagy and protects against TAC-induced cardiac hypertrophy and heart failure . A, 30 days after TAC or sham surgery, αMHC-Cre+/PDE4D-flox/+ mice were su |
| paper_id | 9a10f9ee-2201-47b2-a4ca-b169666a53d9 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11909752/bin/gr7.jpg |
| image_path | |
| description | |
| figure_label | Fig. 7 |
| figure_number | 8 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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