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Figure 7: Inhibitory agents targeting ferroptosis-induced oxidative stress. Ferroptosis is...
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Created: 2026-04-27T05:03:56
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ID: paper-fig-dabb5fb4-3d6c-460d-af8c-b4e1f8
Figure 7Figure 7
Inhibitory agents targeting ferroptosis-induced oxidative stress. Ferroptosis is closely associated with ROS levels; thus, maintaining redox homeostasis is critical for its regulation. The Xc − –GSH–GPX4 axis functions as a primary ROS-scavenging pathway, and various compounds have been designed to modulate ferroptosis by targeting key components of this axis. More recently, the FSP1–CoQ10–NAD(P)H pathway and the mitochondrial DHODH-mediated pathway have emerged as additional regulatory targets of ferroptosis. NRF2 also plays a central role by activating the transcription of genes involved in antioxidant responses, thus serving as a redox-sensitive regulator. Accordingly, targeting the KEAP1–NRF2 axis represents a promising strategy for ferroptosis modulation. Molecules listed in the pink and green boxes act to inhibit or induce the respective redox-regulatory pathways, thereby suppressing or triggering ferroptosis. CBS, cystathionine β-synthase; CoQ10, coenzyme Q10; CTH, cystathionine
▸Metadata
| doi | 10.3389/fimmu.2025.1683876 |
| pmcid | PMC12714665 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12714665/bin/fimmu-16-1683876-g007.jpg', 'type': 'external', 'tracked_at': '2026-04-27T12:03:56.585274'} |
| caption | Inhibitory agents targeting ferroptosis-induced oxidative stress. Ferroptosis is closely associated with ROS levels; thus, maintaining redox homeostasis is critical for its regulation. The Xc − –GSH–G |
| paper_id | dabb5fb4-3d6c-460d-af8c-b4e1f8896611 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12714665/bin/fimmu-16-1683876-g007.jpg |
| image_path | |
| description | |
| figure_label | Figure 7 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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