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Figure 3 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt
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Created: 2026-04-21T18:29:40
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Figure 3Figure 3
Microglial activation and motor impairment by AQP4-IgG requires CNS-infiltrating neutrophils. ( A ) Timeline for injecting neutrophil-depleting anti-Ly6G-IgG or isotype control-IgG (100 mg/kg, i.p.), inserting lumbar subarachnoid catheter, infusing AQP4-IgG, and rotarod testing. ( B ) Flow cytometry confirms neutrophil ablation efficiency (percentage CD45 + CD11b + Gr1 + MPO + cells among peripheral CD45 + CD11b + cells). ( C ) (Upper) t-SNE analysis of CD45 + immune cell subtypes from lumbar spinal cords of control and neutrophil-depleted mice. (Lower) Quantification of data in B (3 mice/group). ( D ) Representative confocal images of neutrophils in lungs of mice receiving neutrophil-depleting anti-Ly6G-IgG or isotype control-IgG (3 mice/group). ( E ) Microglial activation, reflected by Cx3cr1GFP signal, in corresponding lumbar cord regions of mice without and with neutrophil ablation (by Ly6G-IgG or isotype control-IgG) after 3 days’ infusion with normal control mouse IgG or AQP
▸Metadata
| pmid | paper-41665955 |
| caption | Microglial activation and motor impairment by AQP4-IgG requires CNS-infiltrating neutrophils. ( A ) Timeline for injecting neutrophil-depleting anti-Ly6G-IgG or isotype control-IgG (100 mg/kg, i.p.), |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g003.jpg |
| paper_title | Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG. |
| figure_label | Figure 3 |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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