Glymphatic System-Enhanced Antibody Clearance Reversal

**Molecular Mechanism and Rationale** The glymphatic system represents a recently discovered brain-wide clearance mechanism that facilitates the removal of metabolic waste products, including amyloid-beta (Aβ) and tau proteins, through a network of perivascular channels lined by astrocytic endfeet. Central to this system is aquaporin-4 (AQP4), a water channel protein predominantly localized to astrocytic endfeet that maintains the polarized distribution essential for efficient cerebrospinal flu...