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Figure 4 — Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri
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Created: 2026-04-21T18:29:40
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Figure 4Figure 4
Inhibition of pain behavior by the D series resolvin precursor 17(R)‐hydroxy‐docosahexaenoic acid (17[R]‐HDoHE). A and B, Attenuated weight‐bearing asymmetry ( A ) and decreased ipsilateral hind paw withdrawal thresholds ( B ) 14 days after model induction in rats treated with monosodium iodoacetate (MIA) + 17(R)‐HDoHE compared to MIA‐injected vehicle‐treated rats. Bars show the mean ± SEM (n = 8 per group). ## = P < 0.01; ### = P < 0.001 versus saline + vehicle. ∗ = P < 0.05; ∗∗∗ = P < 0.001; ∗∗∗∗ = P < 0.0001 versus MIA + vehicle, by two‐way analysis of variance (ANOVA) with Bonferroni's post hoc test. C and D, Sustained inhibition of weight‐bearing asymmetry ( C ) and decreased paw withdrawal thresholds ( D ) from day 14 to day 28 following repeated administration of 17(R)‐HDoHE in rats treated with MIA compared with rats treated with MIA+ vehicle. Bars show the mean ± SEM. ∗ = P < 0.05; ∗∗ = P < 0.01; ∗∗∗∗ = P < 0.0001 versus MIA + vehicle, by two‐way ANOVA
▸Metadata
| pmid | paper-796580b4c70c |
| caption | Inhibition of pain behavior by the D series resolvin precursor 17(R)‐hydroxy‐docosahexaenoic acid (17[R]‐HDoHE). A and B, Attenuated weight‐bearing asymmetry ( A ) and decreased ipsilateral hind p |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC5763389/bin/ART-69-996-g004.jpg |
| paper_title | Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. |
| figure_label | Figure 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
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