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Extended Data Fig. 3. — Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl
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Created: 2026-04-21T18:29:40
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Extended Data Fig. 3.Figure 3
MTKO mice are susceptible to obesity and have reduced energy expenditure on a high-fat diet. a, Mice were fed a high-fat diet (HFD) beginning at 15 weeks of age, and the percentage weight gain from baseline is plotted. N=10 WT and 12 MTKO mice. b, After the HFD, HOMA-IR was calculated from paired measurements of plasma glucose and insulin. N=7 WT and 10 MTKO mice. c, Immunoblots were done as indicated on hindlimb muscles from mice fed a HFD for 3 weeks. d–f, Body weights and composition of 14-week old MTKO and WT mice fed a HFD for 3 weeks prior to measurements done in metabolic cages. N=7 in each group. g–q, HFD-fed 14-week old MTKO and WT mice were housed in metabolic cages and the indicated parameters were measured. N=7 in each group (g–l, p, q); N=7 WT and 6 MTKO mice (m–o). RER, respiratory exchange ratio; LBM, lean body mass. All data are presented as mean ± SEM of biologically independent samples, analyzed using two-tailed t-tests. *p<0.05, **p<0.01, ***p<0.001.
▸Metadata
| pmid | paper-e86f071aad74 |
| caption | MTKO mice are susceptible to obesity and have reduced energy expenditure on a high-fat diet. a, Mice were fed a high-fat diet (HFD) beginning at 15 weeks of age, and the percentage weight gain from b |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC7990718/bin/nihms-1671263-f0010.jpg |
| paper_title | Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. |
| figure_label | Extended Data Fig. 3. |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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