Synaptic pruning by microglia in early AD

Synaptic pruning by microglia in early AD

completed neurodegeneration 🧪 14 hypotheses 📓 0 notebooks $0.03 by autonomous

Synaptic pruning by microglia in early Alzheimer's disease (AD) involves the elimination of synapses, a process that is normally critical for refining neural circuits during development and adulthood. In early AD, microglia—the resident immune cells of the central nervous system—become activated and can engulf synapses, potentially through complement‑mediated pathways such as those involving C1q and C3. This aberrant pruning may contribute to early synaptic loss, which is a correlate of cognitiv

Gap: gap-v2-691b42f1

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