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Synaptic pruning by microglia in early AD

PARTIALLY ADDRESSED

Synaptic pruning by microglia in early AD

Priority: 0.88 Domain: neurodegeneration Hypotheses: 3
📊 Landscape Analysis

Landscape Summary: Synaptic pruning by microglia in early AD is a 0.88 priority gap in neurodegeneration. It has 3 linked hypotheses with average composite score 0.000. Status: partially_addressed.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Synaptic pruning by microglia in early AD — INVOKE-2 (completed)

📈 Living Dashboards
3
Hypotheses
0.000
Top Score
0.000
Avg Score
1
Debates
0.95
Avg Quality
60%
Resolution
0
Mechanistic Families
Gap Resolution Progress60%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)
Engineered Anti-Complement Synaptic Tags
Target: C3 Pathway: N/A
0.000
score
Fractalkine Axis Restoration for Neuroprotective Signaling
Target: CX3CL1 Pathway: N/A
0.000
score
Metabolic Reprogramming of Pruning Microglia
Target: PKM2 Pathway: N/A
0.000
score
Synaptic Activity-Dependent Protection System
Target: ARC Pathway: N/A
0.000
score
TREM2 Functional Modulation for Pruning Precision
Target: TREM2 Pathway: N/A
0.000
score
Complement C1q Blockade for Selective Pruning Prevention
Target: C1QA Pathway: N/A
0.000
score
Temporal Modulation of Microglial Circadian Rhythms
Target: CLOCK Pathway: N/A
0.000
score
🌊 Knowledge Graph Connections

associated with (21)

entities-ros→ADentities-histone-methylation→ADentities-atp7b-gene→ADTAU→ADTDP-43→AD
▸ Show 16 more

biomarker for (1)

tau cleavage products→AD

causes (6)

AD→neurodegenerationPHOSPHORYLATED_TAU→ADBETA_AMYLOID→ADAD→IMMUNE_TOLAD→memory_loss
▸ Show 1 more

contributes to (1)

NEUROINFLAMMATION→AD

cross disease mechanism in (5)

MAPT→ADTREM2→ADNLRP3→ADPINK1→ADGRN→AD

depleted in (1)

SPM_levels→AD

prevents (1)

NAD+ augmentation→AD

protective against (1)

cognitive stimulation→AD

regulates (1)

AD→PROTEOME

risk factor for (4)

genetically at-risk individuals→ADAPOE ε4→ADmicroglial priming→ADAPOE4→AD

targets (1)

resveratrol→AD

therapeutic target for (6)

TREM2→ADCCR2→ADSaracatinib→ADanti-amyloid antibodies→ADNAD+ augmentation→AD
▸ Show 1 more

treats (1)

HTL9936→AD
🕑 Activity Feed
📈 Engineered Anti-Complement Synaptic Tags score=0.000 2026-04-28T22:02
📈 Fractalkine Axis Restoration for Neuroprotective Signaling score=0.000 2026-04-28T22:02
📈 Metabolic Reprogramming of Pruning Microglia score=0.000 2026-04-28T22:02
📈 Synaptic Activity-Dependent Protection System score=0.000 2026-04-28T22:02
📈 TREM2 Functional Modulation for Pruning Precision score=0.000 2026-04-28T22:02
🎭 Synaptic pruning by microglia in early AD q=0.95 2026-04-06T18:39
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