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CaMK1A Gene
Introduction
Camk1A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@hook2001]
CAMK1A [@soderling2001]
Calcium/Calmodulin-Dependent Protein Kinase 1 Alpha
| | | [@takemotokimura2020] |---|---| [@ghosh1995] | Symbol | CAMK1A | [@bito1997] | Full Name | Calcium/Calmodulin-Dependent Protein Kinase 1 Alpha | [@wayman2008] | Chromosome | 3p25.3 | [@skelding2012] | NCBI Gene ID | [85369](https://www.ncbi.nlm.nih.gov/gene/85369) | | OMIM | [610447](https://www.omim.org/entry/610447) | | Ensembl ID | [ENSG00000155111](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155111) | | UniProt ID | [Q9UQB8](https://www.uniprot.org/uniprot/Q9UQB8) | | Encoded Protein | [CaMK1A Protein](/proteins/camk1a-protein) | | Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Cognitive Impairment](/diseases/mild-cognitive-impairment) |
</div>
Overview
The CAMK1A gene encodes CaMK1A Protein, a Calcium/calmodulin-dependent protein kinase that plays critical roles in Serine/threonine protein kinase activated by calcium/calmodulin. This gene is implicated in the pathogenesis of several neurodegenerative diseases through its involvement in neuronal signaling, synaptic plasticity, gene transcription.
Function
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CaMK1A Gene
Introduction
Camk1A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@hook2001]
CAMK1A [@soderling2001]
Calcium/Calmodulin-Dependent Protein Kinase 1 Alpha
| | | [@takemotokimura2020] |---|---| [@ghosh1995] | Symbol | CAMK1A | [@bito1997] | Full Name | Calcium/Calmodulin-Dependent Protein Kinase 1 Alpha | [@wayman2008] | Chromosome | 3p25.3 | [@skelding2012] | NCBI Gene ID | [85369](https://www.ncbi.nlm.nih.gov/gene/85369) | | OMIM | [610447](https://www.omim.org/entry/610447) | | Ensembl ID | [ENSG00000155111](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000155111) | | UniProt ID | [Q9UQB8](https://www.uniprot.org/uniprot/Q9UQB8) | | Encoded Protein | [CaMK1A Protein](/proteins/camk1a-protein) | | Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Cognitive Impairment](/diseases/mild-cognitive-impairment) |
</div>
Overview
The CAMK1A gene encodes CaMK1A Protein, a Calcium/calmodulin-dependent protein kinase that plays critical roles in Serine/threonine protein kinase activated by calcium/calmodulin. This gene is implicated in the pathogenesis of several neurodegenerative diseases through its involvement in neuronal signaling, synaptic plasticity, gene transcription.
Function
CAMK1A encodes a member of the Ca2+/calmodulin-dependent protein kinase (CaMK) family. CaMK1A is a serine/threonine protein kinase that requires calcium and calmodulin for activation. Upon calcium influx, CaMK1A phosphorylates various downstream targets including transcription factors, ion channels, and other kinases. In [neurons](/entities/neurons), CaMK1A plays important roles in synaptic plasticity, learning and memory, and neuronal development. It is activated by calcium influx through NMDA receptors and voltage-gated calcium channels, and phosphorylates targets involved in synaptic vesicle cycling and gene expression regulation.
In Alzheimer's disease, CaMK1A signaling may be impaired due to [amyloid-beta](/proteins/amyloid-beta)-induced synaptic dysfunction and calcium dysregulation. CaMK1A-mediated phosphorylation of synaptic proteins is important for synaptic plasticity, and disruption of this pathway may contribute to memory impairment. In Parkinson's disease, CaMK1A may play protective roles in dopaminergic neurons, and altered CaMK1A signaling has been observed in animal models of PD.
Expression
CAMK1A is primarily expressed in the brain, with highest expression in the cerebral [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), and cerebellum. It is localized to both neuronal cell bodies and [dendritic spines](/cell-types/dendritic-spines), where it participates in synaptic signaling.
The study of Camk1A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Colbran RJ, Brown AM, Calcium/calmodulin-dependent protein kinases (2004)](https://pubmed.ncbi.nlm.nih.gov/15194107/)
[Hook SS, Means AR, Ca2+/CaM-dependent kinases: From activation by calcium to integrative regulation of cellular function (2001)](https://pubmed.ncbi.nlm.nih.gov/11264464/)
[Soderling TR, Stull JT, Structure and regulation of calcium/calmodulin-dependent protein kinases (2001)](https://pubmed.ncbi.nlm.nih.gov/11749377/)
[Takemoto-Kimura S, Suzuki K, Horigane S, et al, Roles of CaMK1 in neuronal development and function (2020)](https://pubmed.ncbi.nlm.nih.gov/32082191/)
[Ghosh A, Greenberg ME, Calcium signaling in neurons: Molecular mechanisms and cellular consequences (1995)](https://pubmed.ncbi.nlm.nih.gov/7716515/)
[Wayman GA, Lee YS, Tokumitsu H, et al, Calmodulin kinases: Modulators of neuronal development and plasticity (2008)](https://pubmed.ncbi.nlm.nih.gov/18817731/)
[Skelding KA, Rostas JA, Regulation of CaMKII in vivo: Mechanisms for spatial and temporal control (2012)](https://pubmed.ncbi.nlm.nih.gov/22292454/)