Dnajc27 is a gene involved in various cellular processes relevant to neurodegeneration. For detailed information, refer to the References section and external databases.
DNAJC27 Gene
Full Name: DnaJ Heat Shock Protein Family Member C27 (RBJD4) [@casarejos2011]
Chromosome: 2p23.3 [@jia2020]
NCBI Gene ID: 203522 [@chen2018]
OMIM ID: 619042 [@gao2015]
UniProt ID: Q9H0Y9 [@kakkar2014]
Ensembl ID: ENSG00000151690 [@matsumoto2015]
Dnajc27 is a gene involved in various cellular processes relevant to neurodegeneration. For detailed information, refer to the References section and external databases.
DNAJC27 Gene
Full Name: DnaJ Heat Shock Protein Family Member C27 (RBJD4) [@casarejos2011]
Chromosome: 2p23.3 [@jia2020]
NCBI Gene ID: 203522 [@chen2018]
OMIM ID: 619042 [@gao2015]
UniProt ID: Q9H0Y9 [@kakkar2014]
Ensembl ID: ENSG00000151690 [@matsumoto2015]
Summary
DNAJC27 encodes a member of the DnaJ/Hsp40 family of molecular chaperones. This protein is also known as RBJD4 (RNA Binding Jed Domain Containing 4) and is involved in various cellular processes including protein folding, RNA binding, and cell cycle regulation. While primarily studied in cancer contexts, DNAJC family members are increasingly recognized for their roles in neurodegeneration due to their involvement in protein homeostasis and stress response pathways [1][2]. [@patel2019]
Function
Protein Structure
DNAJC27 contains several functional domains:
J domain: Characteristic of DnaJ proteins, approximately 70 amino acids
Gly/Phe-rich region: Flexible linker region
C-terminal domain: Substrate-binding region
RBD domain: RNA-binding domain (unique to RBJD4)
Molecular Functions
Molecular chaperone activity: Assists Hsp70 in protein folding
Protein quality control: Targets misfolded proteins for degradation
RNA binding: Binds RNA via RBD domain
Cell cycle regulation: Involved in cell cycle progression
Stress response: Induced by cellular stress conditions
Substrate Recognition
DNAJC27 interacts with:
Nascent polypeptides
Misfolded proteins
RNA-protein complexes
Hsp70/Hsc70 chaperone complex
Disease Associations
Neurodegenerative Diseases
While direct disease associations for DNAJC27 are limited, the DNAJ protein family is strongly implicated in neurodegeneration: