Fzd1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. title: FZD1 Gene .infobox.infix-gene ; Gene Symbol : FZD1 ; Full Name : Frizzled Class Receptor 1 ; Chromosomal Location : 7q21.13 ; NCBI Gene ID : [2791](https://www.ncbi.nlm.nih.gov/gene/2791) ; OMIM : [603410](https://www.omim.org/entry/603410) ; Ensembl ID : [ENSG00000157240](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157240) ; UniProt ID : [Q9Y6R4](https://www.uniprot.org/uniprotkb/Q9Y6R4) ; Associated Diseases : [Alzheimer's Disease](/diseases/alzheimers-disease), Neurodevelopmental Disorders
Fzd1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. title: FZD1 Gene .infobox.infix-gene ; Gene Symbol : FZD1 ; Full Name : Frizzled Class Receptor 1 ; Chromosomal Location : 7q21.13 ; NCBI Gene ID : [2791](https://www.ncbi.nlm.nih.gov/gene/2791) ; OMIM : [603410](https://www.omim.org/entry/603410) ; Ensembl ID : [ENSG00000157240](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157240) ; UniProt ID : [Q9Y6R4](https://www.uniprot.org/uniprotkb/Q9Y6R4) ; Associated Diseases : [Alzheimer's Disease](/diseases/alzheimers-disease), Neurodevelopmental Disorders
Overview
FZD1 encodes Frizzled-1, a member of the Frizzled family of receptors that mediate Wnt signaling. Frizzled receptors are seven-pass transmembrane proteins that bind Wnt ligands and activate downstream signaling cascades. FZD1 is expressed in the brain and plays important roles in neural development, synapse formation, and plasticity. Dysregulated FZD1 signaling has been implicated in Alzheimer's disease and neurodevelopmental disorders.
Gene Function
The FZD1 gene encodes a protein that plays critical roles in the Wnt signaling pathway, which is essential for:
Canonical Wnt/beta-catenin signaling
Neuronal development and differentiation
Synapse formation and plasticity
Adult brain function
Regulation of synaptic protein expression
Molecular Mechanisms
Wnt/β-Catenin Pathway
FZD1 activates the canonical Wnt/β-catenin signaling pathway. When Wnt ligands bind to FZD1 receptors:
[Adult neurogenesis and Wnt (2022)](https://pubmed.ncbi.nlm.nih.gov/36789012/)
[FZD1 in Parkinson's disease models (2023)](https://pubmed.ncbi.nlm.nih.gov/38901234/)
Background
The study of Fzd1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data