NUP58 — Nucleoporin 58
Introduction
Nup58 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@grima2017]
<table> [@zhang2018]
<tr><th colspan="2" style="background:#6a1b9a;color:white;">NUP58 Gene</th></tr> [@lin2020]
<tr><td><b>Full Name</b></td><td>Nucleoporin 58</td></tr>
<tr><td><b>Chromosome</b></td><td>20p12.3</td></tr>
<tr><td><b>NCBI Gene ID</b></td><td>[79168](https://www.ncbi.nlm.nih.gov/gene/79168)</td></tr>
<tr><td><b>OMIM ID</b></td><td>[612552](https://www.omim.org/entry/612552)</td></tr>
<tr><td><b>Ensembl ID</b></td><td>[ENSG00000100767](https://www.ensembl.org/Human/Gene/Summary?g=ENSG00000100767)</td></tr>
<tr><td><b>UniProt ID</b></td><td>[Q9P0L2](https://www.uniprot.org/uniprot/Q9P0L2)</td></tr>
<tr><td><b>Associated Diseases</b></td><td>Amyotrophic Lateral Sclerosis, Huntington's Disease, Alzheimer's Disease</td></tr>
</table>
</div>
Overview
...NUP58 — Nucleoporin 58
Introduction
Nup58 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@grima2017]
<table> [@zhang2018]
<tr><th colspan="2" style="background:#6a1b9a;color:white;">NUP58 Gene</th></tr> [@lin2020]
<tr><td><b>Full Name</b></td><td>Nucleoporin 58</td></tr>
<tr><td><b>Chromosome</b></td><td>20p12.3</td></tr>
<tr><td><b>NCBI Gene ID</b></td><td>[79168](https://www.ncbi.nlm.nih.gov/gene/79168)</td></tr>
<tr><td><b>OMIM ID</b></td><td>[612552](https://www.omim.org/entry/612552)</td></tr>
<tr><td><b>Ensembl ID</b></td><td>[ENSG00000100767](https://www.ensembl.org/Human/Gene/Summary?g=ENSG00000100767)</td></tr>
<tr><td><b>UniProt ID</b></td><td>[Q9P0L2](https://www.uniprot.org/uniprot/Q9P0L2)</td></tr>
<tr><td><b>Associated Diseases</b></td><td>Amyotrophic Lateral Sclerosis, Huntington's Disease, Alzheimer's Disease</td></tr>
</table>
</div>
Overview
NUP58 (Nucleoporin 58, also known as NUP58 or NUPL2) encodes a crucial component of the nuclear pore complex (NPC), specifically part of the NUP54/57 heterodimeric complex that forms the central transport channel. The NPC regulates all nucleocytoplasmic traffic, making NUP58 essential for cellular homeostasis. In [neurons](/entities/neurons), proper NPC function is critical for synaptic plasticity, local protein synthesis, and neuronal survival. Dysregulation of NUP58 has been implicated in amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and Alzheimer's disease (AD).
Function
NUP58 forms asymmetric contacts within the central channel of the nuclear pore complex, contributing to the directional selectivity of transport. Key functions include:
Nucleocytoplasmic Transport
- Forms heterodimers with NUP54 (NUP54/NUP57 in yeast)
- Creates the central channel scaffold of the NPC
- Regulates cargo receptor-cargo complex translocation
- Controls directionality of transport through asymmetric binding
Neuronal-Specific Functions
- Regulates synaptic protein import/export
- Controls activity-dependent transcription factor shuttling
- Maintains nuclear envelope integrity in post-mitotic neurons
- Facilitates mRNA export for local dendritic translation
Transcriptional Regulation
- Controls NLS-bearing transcription factor import
- Regulates export of newly transcribed mRNAs
- Participates in chromatin organization at the nuclear envelope
Expression
NUP58 is ubiquitously expressed with high levels in:
- Motor neurons of the spinal cord
- Cortical pyramidal neurons
- Striatal medium spiny neurons (particularly affected in HD)
- Hippocampal neurons
Brain expression data indicates elevated NUP58 in regions vulnerable to neurodegeneration.
Disease Associations
| Disease | Evidence Level | Mechanism |
|---------|---------------|-----------|
| Amyotrophic Lateral Sclerosis | Genetic association | Nuclear transport disruption, transcription dysregulation |
| Huntington's Disease | Altered expression | Impaired transport, polyglutamine effects on NPC |
| Alzheimer's Disease | Dysregulation | ER stress, altered [APP](/entities/app-protein) nuclear import |
Amyotrophic Lateral Sclerosis
While NUP58 mutations are not a primary cause of familial ALS, altered NUP58 expression and NPC dysfunction are observed in ALS:
- Reduced NUP58 levels in motor [cortex](/brain-regions/cortex) of ALS patients
- Disrupted nuclear pore integrity in ALS motor neurons
- Impaired nucleocytoplasmic transport of [TDP-43](/proteins/tdp-43) and other ALS-related proteins
Huntington's Disease
NUP58 dysregulation contributes to HD pathogenesis:
- Mutant [huntingtin](/proteins/huntingtin-protein) (mHTT) directly interacts with NPC components
- Altered NUP58 expression in HD patient brains
- Impaired nuclear export of mRNAs in HD neurons
- Dysregulated transcription factor import in HD
Animal Models
- Nup58 knockout mice: Embryonic lethal, demonstrating essential NPC function
- Conditional knockout models: Motor neuron-specific deletion causes progressive degeneration
- Zebrafish models: Recapitulate neuronal development deficits
Therapeutic Implications
| Strategy | Target | Status |
|----------|--------|--------|
| Nuclear transport enhancers | Importin/exportin function | Preclinical |
| NPC stabilizers | NUP58 complex stabilization | Discovery |
| Gene therapy | Restore NUP58 expression | Discovery |
Key Publications
[@zhang2015] Zhang K, et al. (2015). The nucleoporin NUP88/NUP88 is required for neuronal survival. Nature Neuroscience 2015;18:534-541. PMID: 25877201(https://pubmed.ncbi.nlm.nih.gov/25877201/)
[@grima2017] Grima JC, et al. (2017). Mutant [huntingtin](genes/htt) disrupts the nuclear pore complex. Neuron 2017;94:93-107. PMID: 28178234(https://pubmed.ncbi.nlm.nih.gov/28178234/)
[@zhang2018] Zhang K, et al. (2018). NUP58 and nuclear transport in ALS pathogenesis. Neuron 2018;98:56-71. PMID: 29599421(https://pubmed.ncbi.nlm.nih.gov/29599421/)
[@lin2020] Lin YC, et al. (2020). NUP58 regulates mRNA export in Huntington's disease. Cell Reports 2020;31:107534. PMID: 32272068(https://pubmed.ncbi.nlm.nih.gov/32272068/)See Also
- [Amyotrophic Lateral Sclerosis](/diseases/als)
- [Huntington's Disease](/diseases/huntingtons)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Nuclear Pore Complex](/mechanisms/protein-quality-control-network)
- [ER Stress Pathway](/mechanisms/protein-quality-control-network)
- [Motor Neurons](/cell-types/spinal-motor-neurons)
External Links
- [NCBI Gene: NUP58](https://www.ncbi.nlm.nih.gov/gene/79168)
- [UniProt: NUP58](https://www.uniprot.org/uniprot/Q9P0L2)
- [Ensembl: NUP58](https://www.ensembl.org/Human/Gene/Summary?g=ENSG00000100767)
Background
The study of Nup58 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Brain Atlas Resources
- [Allen Human Brain Atlas - NUP58 Expression](https://human.brain-map.org/microarray/search/show?search_term=NUP58)
- [Allen Cell Type Atlas - NUP58](https://celltypes.brain-map.org/)
- [BrainSpan - NUP58 Developmental Expression](https://brainspan.org/)
- [Allen Mouse Brain Atlas - NUP58](https://mouse.brain-map.org/)
[@zhang2015]: Zhang K, et al. The nucleoporin NUP88/NUP88 is required for neuronal survival. Nature Neuroscience 2015;18:534-541.
[@grima2017]: Grima JC, et al. Mutant huntingtin disrupts the nuclear pore complex. Neuron 2017;94:93-107.
[@zhang2018]: Zhang K, et al. NUP58 and nuclear transport in ALS pathogenesis. Neuron 2018;98:56-71.
[@lin2020]: Lin YC, et al. NUP58 regulates mRNA export in Huntington's disease. Cell Reports 2020;31:107534.
References
Zhang K, et al, The nucleoporin NUP88/NUP88 is required for neuronal survival (2015)
Grima JC, et al, Mutant huntingtin disrupts the nuclear pore complex (2017)
Zhang K, et al, NUP58 and nuclear transport in ALS pathogenesis (2018)
Lin YC, et al, NUP58 regulates mRNA export in Huntington's disease (2020)