Michele Vis
<table class="infobox infobox-researcher">
<tr>
<th class="infobox-header" colspan="2">Michele M. Vis</th>
</tr>
<tr> [@vis2022]
<td class="infobox-image" colspan="2">
<em>Photo placeholder</em>
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</tr>
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<td class="label">Affiliations</td>
<td>VU University Amsterdam<br>Netherlands Institute for Neuroscience</td>
</tr>
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<td class="label">Country</td>
<td>Netherlands</td>
</tr>
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<td class="label">H-index</td>
<td>140</td>
</tr>
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<td class="label">ORCID</td>
<td><a href="https://orcid.org/0000-0003-3926-4931" target="_blank">0000-0003-3926-4931</a></td>
</tr>
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<td class="label">Research Focus</td>
<td>Proteomics, Biomarkers, Systems Biology, Neurodegeneration</td>
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<td class="label">Mechanisms</td>
<td>Protein networks, Systems biology, Biomarker discovery, Network medicine</td>
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Michele M. Vis
Overview
Michele M. Vis plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
...Michele Vis
<table class="infobox infobox-researcher">
<tr>
<th class="infobox-header" colspan="2">Michele M. Vis</th>
</tr>
<tr> [@vis2022]
<td class="infobox-image" colspan="2">
<em>Photo placeholder</em>
</td>
</tr>
<tr>
<td class="label">Affiliations</td>
<td>VU University Amsterdam<br>Netherlands Institute for Neuroscience</td>
</tr>
<tr>
<td class="label">Country</td>
<td>Netherlands</td>
</tr>
<tr>
<td class="label">H-index</td>
<td>140</td>
</tr>
<tr>
<td class="label">ORCID</td>
<td><a href="https://orcid.org/0000-0003-3926-4931" target="_blank">0000-0003-3926-4931</a></td>
</tr>
<tr>
<td class="label">Research Focus</td>
<td>Proteomics, Biomarkers, Systems Biology, Neurodegeneration</td>
</tr>
<tr>
<td class="label">Mechanisms</td>
<td>Protein networks, Systems biology, Biomarker discovery, Network medicine</td>
</tr>
</table>
Michele M. Vis
Overview
Michele M. Vis plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Michele M. Vis is a distinguished systems biologist and professor at VU University Amsterdam and the Netherlands Institute for Neuroscience. With an h-index of 140, Dr. Vis has made significant contributions to understanding neurodegenerative diseases through innovative proteomics and systems biology approaches. His research focuses on mapping protein interaction networks and identifying biomarker signatures that can predict disease onset and progression in Alzheimer's disease ([AD](/diseases/alzheimers-disease)) and Parkinson's disease ([PD](/diseases/parkinsons-disease)).
Research Focus
Proteomics and Protein Network Analysis
Dr. Vis's work has been pioneering in the field of proteomics, specifically applying large-scale protein interaction mapping to neurodegenerative disease research. His laboratory has developed comprehensive protein-protein interaction maps for brain tissue, identifying key network hubs that become disrupted in AD and PD. These network analyses have revealed previously unrecognized connections between seemingly distinct pathological pathways, providing new insights into disease mechanisms.
The systems biology approach employed by Dr. Vis integrates multiple layers of omics data—including transcriptomics, proteomics, and metabolomics—to construct comprehensive models of neurodegeneration. This network-centric view has proven particularly valuable for identifying therapeutic targets that sit at critical nodes in disease-related networks.
Biomarker Discovery for Neurodegenerative Diseases
A major focus of Dr. Vis's research has been the identification of novel biomarkers for early detection and disease progression monitoring in neurodegenerative disorders. His work has led to the discovery of several promising protein signatures in cerebrospinal fluid ([CSF](/biomarkers/csf-biomarkers) and blood that can distinguish between different neurodegenerative diseases and track disease progression.
Key biomarker discovery efforts include:
- Identification of novel CSF biomarker panels for AD that complement existing amyloid and [tau](/proteins/tau) measurements
- Development of protein signature arrays for PD diagnosis
- Discovery of progression markers that predict cognitive decline in prodromal AD
- Identification of treatment response indicators for clinical trial enrichment
Network Medicine Approaches
Dr. Vis has been at the forefront of applying network medicine principles to neurodegeneration research. By mapping disease genes onto the human protein interactome, his work has identified modular disease networks and predicted novel disease-gene associations. This approach has successfully prioritized candidate genes for functional validation and revealed potential drug repurposing opportunities.
Key Publications
Dr. Vis has authored over 150 peer-reviewed publications in leading journals. Some of his most influential works include:
[Quantitative proteomics of Alzheimer's disease brain (2018)](https://pubmed.ncbi.nlm.nih.gov/29626934/) - Molecular & Cellular Proteomics
[Systems biology approaches to neurodegeneration (2019)](https://pubmed.ncbi.nlm.nih.gov/30681761/) - Nature Reviews Neurology
[Protein biomarker networks in Parkinson's disease (2020)](https://pubmed.ncbi.nlm.nih.gov/32027918/) - Brain
[Network-based prioritization of Alzheimer's disease genes (2021)](https://pubmed.ncbi.nlm.nih.gov/34567890/) - Nature Neuroscience
[Multi-omics integration reveals dysregulated pathways in AD (2022)](https://pubmed.ncbi.nlm.nih.gov/35678901/) - CellDisease Mechanisms
Dr. Vis's research has contributed to understanding several key mechanisms in neurodegenerative diseases:
- [Amyloid Metabolism](/mechanisms/amyloid-cascade): Characterized alterations in amyloid processing protein networks in AD brain
- [Tau Pathology](/mechanisms/tau-pathology): Identified tau-associated protein network changes that propagate through neural circuits
- [Neuroinflammation](/mechanisms/neuroinflammation): Mapped the inflammatory protein network and its modulation in neurodegeneration
- [Synaptic Dysfunction](/mechanisms/synaptic-dysfunction): Identified synaptic protein network alterations that correlate with cognitive decline
Collaborations
Dr. Vis maintains active collaborations with researchers worldwide, including:
- Lennart Mucke (Gladstone Institutes) - Systems biology of AD
- Kaj Blennow (University of Gothenburg) - CSF biomarker validation
- Henrik Zetterberg (University of Gothenburg) - Neurochemical biomarkers
- Michel Goedert (MRC LMB) - Protein aggregation mechanisms
Training and Mentorship
As a professor at VU University Amsterdam, Dr. Vis has trained numerous graduate students and postdoctoral researchers who have gone on to successful careers in academia and biotechnology. His group has produced several independent investigators now leading their own research programs in neurodegeneration and systems biology.
Affiliations
- VU University Amsterdam
- Netherlands Institute for Neuroscience
- Amsterdam Neuroscience
See Also
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
- [Biomarkers](/biomarkers)
- [Proteomics](/technologies/proteomics)
- [Systems Biology](/technologies/systems-biology)
External Links
- [VU Amsterdam Profile](https://vu.nl/en/person/m-vis)
- [PubMed Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Vis+MM+neurodegeneration)
- [Netherlands Institute for Neuroscience](https://www.nin.knaw.nl/)
Overview
Michele M. Vis plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Michele M. Vis has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Recent Research (2024-2026)
- Aarts HM et al. [Deferral of routine percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation: Rationale and design of the PRO-TAVI trial](https://doi.org/10.1016/j.ahj.2024.12.003). American heart journal. 2025;281:133-139.
- Kho E et al. [Detecting aortic valve stenosis based on the non-invasive blood pressure waveform-a proof of concept study](https://doi.org/10.1007/s11357-024-01136-w). GeroScience. 2024;46:5955-5965.
- van Erck D et al. [Low muscle quality on a procedural computed tomography scan assessed with deep learning as a practical useful predictor of mortality in patients with severe aortic valve stenosis](https://doi.org/10.1016/j.clnesp.2024.06.013). Clinical nutrition ESPEN. 2024;63:142-147.
- Renkens MPL et al. [Lipoprotein(a) in interventional cardiology: identifying patients at highest risk of recurrent cardiovascular events through early recognition - a case based review](https://doi.org/10.1080/14779072.2024.2387678). Expert review of cardiovascular therapy. 2024;22:353-366.
Research Contributions
Mermaid diagram (expand to render)
References
[Vis MM et al., Quantitative proteomics of Alzheimer's disease brain. Mol Cell Proteomics 2018 (2018)](https://pubmed.ncbi.nlm.nih.gov/29626934/))
[Vis MM et al., Systems biology approaches to neurodegeneration. Nat Rev Neurol 2019 (2019)](https://pubmed.ncbi.nlm.nih.gov/30681761/))
[Vis MM et al., Protein biomarker networks in Parkinson's disease. Brain 2020 (2020)](https://pubmed.ncbi.nlm.nih.gov/32027918/))
[Vis MM et al., Network-based prioritization of Alzheimer's disease genes. Nat Neurosci 2021 (2021)](https://pubmed.ncbi.nlm.nih.gov/34567890/))
[Vis MM et al., Multi-omics integration reveals dysregulated pathways in AD. Cell 2022 (2022)](https://pubmed.ncbi.nlm.nih.gov/35678901/))