Acetylcholine

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease

0.97 · therapeutic

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD

0.96 · therapeutic

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau propagation and restore entorhinal-hippocampal gamma synchrony in early Alzheimer's dise

0.96 · therapeutic

Cortico-Striatal Synchrony Restoration via NMDA Modulation

0.95 · mechanistic

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron neuromodulation in Alzheimer's disease

0.91 · therapeutic

Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible

0.89 · combination

Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance

0.88 · therapeutic

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD

0.87 · therapeutic

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease

0.87 · therapeutic

Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activation using implantable LED arrays in Alzheimer's disease

0.87 · therapeutic

What is the optimal dosage and timing of melatonin administration for AD prevention and treatment?

What determines the temporal sequence of cholinergic dysfunction versus amyloid/tau pathology in human AD?

How do metabolomic alterations in glucose metabolism, mitochondrial function, and neurotransmitter biosynthesis contribute to Alzheimer disease progre

Gamma entrainment therapy to restore hippocampal-cortical synchrony

Pathway diagram for CHRNA7

Figure 4.: Direct effects of acetylcholine on DMG (A) Timeline for the generation of iPSC-d...

Figure 3.: Mechanisms of activity-regulated midbrain cholinergic neuron-to-glioma signaling...

Figures — The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mo

Figures — Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behaviora

Figures — High Glucose Restraint of Acetylcholine-Induced Keratinocyte Epithelial-Mesenchy

FIGURE 3: Schematic diagram of a plasma membrane, depicting the spatial relationship betwe...

Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to resto approved

Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to approved

APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…

Closed-loop optogenetic targeting PV interneurons to restore theta-gamma couplin approved

Mitochondrial biogenesis stimulation via PGC-1α in early-stage AD neurons. Energy deficit precedes a…

Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga approved

Neurogenesis enhancement in hippocampal dentate gyrus via BDNF gene delivery to counteract memory ci…

Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to rejected

Broad proteostasis network upregulation via HSF1 activation. Overallocated token request to cover co…