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Figure 3.: Mechanisms of activity-regulated midbrain cholinergic neuron-to-glioma signaling...
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Figure 3.Figure 3
Mechanisms of activity-regulated midbrain cholinergic neuron-to-glioma signaling (A) Quantification of glioma cell proliferation (EdU + /HNA + ) in DMG cells exposed to conditioned medium (CM) from LDT or PPN midbrain explants following cholinergic neuronal optogenetic stimulation. One-way analysis of variance (ANOVA) with Tukey’s post hoc analysis; ** p < 0.01, *** p < 0.001. Data = mean ± SEM; n = three independent experiments, each with three wells per condition; each data point represents the mean of three wells per condition for a given experiment. (B and C) Measurement of BDNF and acetylcholine levels in midbrain explant CM from (B) LDT and (C) PPN. Data = mean ± SEM; n = three independent experiments, each with three wells per condition; each data point represents the mean of three wells per condition for a given experiment. (D and E) Schematic of the experimental paradigm and representative image showing the recording site for GRAB-ACh3.0 sensor experiment, performed to m
▸Metadata
| doi | 10.1016/j.cell.2025.05.031 |
| pmcid | PMC12396346 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12396346/bin/nihms-2096866-f0004.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:07:49.609204'} |
| caption | Mechanisms of activity-regulated midbrain cholinergic neuron-to-glioma signaling (A) Quantification of glioma cell proliferation (EdU + /HNA + ) in DMG cells exposed to conditioned medium (CM) from LD |
| paper_id | 640f626a-ad3e-4ccf-a806-fbe18cc83b81 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12396346/bin/nihms-2096866-f0004.jpg |
| image_path | |
| description | |
| figure_label | Figure 3. |
| figure_number | 3 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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