Biomarker Validation
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32
hypotheses
18
debates
1
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization
85% yes
💬 3
0.89
· therapeutic
0.74
· mechanistic
Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Antagonist in Tau Phase
💬 4
0.73
· clinical
0.73
· mechanistic
0.72
· combination
0.71
· combination
0.70
· combination
0.69
· combination
0.69
💬 Debates & Sessions
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💬
Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-cortical connectivity in early MCI
hypothesis_debate · 2026-04-27
· score 0.9
💬
Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.9
💬
Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV interneurons to restore AnkyrinG-dependent AIS integrity and hippocampal g
hypothesis_debate · 2026-04-27
· score 0.7
💬
Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagation and restore perforant-path gamma gating in AD
hypothesis_debate · 2026-04-27
· score 0.7
💬
Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via indirect somatostatin interneuron disinhibition in A
hypothesis_debate · 2026-04-27
· score 0.9
💬
Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD
hypothesis_debate · 2026-04-27
· score 0.5
🔍 Knowledge Gaps
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Can qualitative research methods be systematically integrated into neurodegeneration biomarker validation studies?
clinical-research-methodology
📋 Notebooks & Artifacts
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🧪
experiment · 2026-04-02
🏆 Active Challenges
Resolve: blood MMP-9/TIMP-1 ratio predicts early BBB tight-junction proteolysis
$500,000 bounty
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📨 Allocation Proposals
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