🧫
Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Markers
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-epigenet
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.904947Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['KDM6A/SIRT1/TET2'], 'diseases': ['Neurodegeneration']} |
| model_system | human |
| summary | # Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Markers ## Background and Rationale Epigenetic clocks represent sophisticated molecular chronometers that quantify biological aging |
| replication_status | single_study |
| methodology_notes | **Phase 1: Cohort Recruitment and Clinical Assessment (Months 1-6)** • Recruit n=300 participants across 4 groups: healthy controls (n=75), mild cognitive impairment (MCI, n=75), Alzheimer's disease |
| primary_outcome | Validate Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Markers |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.904955'} |
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