🧫
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-progranu
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.900227Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['TDP'], 'diseases': ['ALS']} |
| model_system | human |
| summary | # Mechanism: Progranulin Loss and TDP-43 Pathology in FTD ## Background and Rationale Frontotemporal dementia (FTD) represents the second most common early-onset dementia, with heterozygous mutations |
| replication_status | single_study |
| methodology_notes | Phase 1: Post-mortem tissue analysis (Weeks 1-8). Collect frozen frontal/temporal cortex samples from GRN mutation carriers (n=20), sporadic FTD cases (n=20), and age-matched controls (n=15). Perform |
| primary_outcome | Validate Mechanism: Progranulin Loss and TDP-43 Pathology in FTD |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.900232'} |
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