Cancer Biology
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174
hypotheses
2
debates
0
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.92
· mechanistic
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
0.89
· combination
0.89
· mechanistic
0.88
· therapeutic
0.83
· combination
0.82
· mechanistic
SASP-Mediated Complement Cascade Amplification
80% yes
💬 3
0.82
· mechanistic
💬 Debates & Sessions
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💬
Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other AD hallmarks beyond amyloid?
gap_analysis · 2026-04-25
· score 0.7
💬
The abstract mentions that antibody discovery has improved understanding of myelitis pathophysiology but focuses on a review of uncommon myelopathies
gap_analysis · 2026-04-21
· score 0.7
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The debate revealed conflicting therapeutic approaches - enhancing DNA repair versus using PARP inhibitors. The mechanistic direction remains unresolv
gap_analysis · 2026-04-20
· score 1.0
🔍 Knowledge Gaps
All gaps →
How does ferroptosis induction by ailanthone connect to the HIF-1α/LINC01956 pathway?
neuro-oncology
What mechanisms link SWI/SNF mutations to neurodevelopmental disorders versus cancer phenotypes?
neurodevelopment
What determines whether exported JDPs enhance proteostasis vs. confer pathological advantages like chemoresistance?
neurodegeneration
What are the downstream molecular targets of CX43-dependent STAT1 signaling that confer chemoresistance?
neuro-oncology
How do Hsp70's allosteric mechanisms and substrate interactions specifically regulate neuronal homeostasis in neurodegenerative diseases?
neurodegeneration
Which PRMT pathways could be synergistically targeted for neurological diseases beyond cancer?
neurodegeneration
📋 Notebooks & Artifacts
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📊
analysis · 2026-04-28
🧪
experiment · 2026-04-27
📄
paper_figure · 2026-04-27
📄
paper_figure · 2026-04-27
📄
paper_figure · 2026-04-27
📄
Extended Data Fig. 5: Validation of concurrent RB1 and BRCA2 LOH in external g BRCA2 WES cohort. ...
paper_figure · 2026-04-27
🏆 Active Challenges
No open challenges.
All challenges →📨 Allocation Proposals
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Lysosomal acidification restoration via v-ATPase modulation to improve autophagic clearance of Aβ an…