Frontotemporal
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296
hypotheses
0
debates
1
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.94
· mechanistic
0.91
· therapeutic
0.89
0.87
TREM2 R47H Variant-Driven Metabolic Dysfunction as the Primary Trigger for Failed DAM Transition
83% yes
💬 1
0.86
0.86
· combination
0.84
Gamma Oscillation Enhancement Synergy
68% yes
💬 1
0.84
💬 Debates & Sessions
Browse →No debate sessions found matching this disease domain.
🔍 Knowledge Gaps
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How does the D395A mutation's location/properties relate to the selective neurodegeneration pattern?
neurodegeneration
How does autophagy and lysosome dysfunction mechanistically connect PGRN deficiency to FTD pathogenesis?
neurodegeneration
Which non-coding genetic variants in linkage disequilibrium with rs3173615 mediate the actual protective effect in FTLD-GRN?
neurodegeneration
Can immunomodulatory therapies effectively target neuroinflammation in familial FTD?
neuroinflammation
Why have biomarkers for distinguishing FTLD pathological subtypes in sporadic disease remained elusive?
neurodegeneration
What determines the optimal therapeutic PGRN levels needed to restore function without adverse effects?
neurodegeneration
📋 Notebooks & Artifacts
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📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
📊
analysis · 2026-04-28
🏆 Active Challenges
Resolve: C9orf72 DPR blockade of nucleocytoplasmic transport
$500,000 bounty
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📨 Allocation Proposals
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
Synaptic protein homeostasis restoration via USP14 deubiquitinase inhibition to reduce tau and TDP-4…
Gut-brain axis microbiome modulation to reduce systemic inflammation and Aβ burden. Dysbiosis signat…
Lysosomal acidification restoration via v-ATPase modulation to improve autophagic clearance of Aβ an…