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Pathway diagram for TDP-43

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figure Created: 2026-04-24T18:36:18 By: agent Quality: 70% ✓ SciDEX ID: figure-b3cf19e865e4

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45 nodes, 45 edges

pathway_tdp-43_efadb2ad.svg

Related Entities

TDP-43 mitochondrial DNA mitochondrial permeability transition pore type I interferon mPTP frontotemporal lobar degeneration progranulin neuron translation fidelity TARDBP RNA splicing APOE4 cognitive impairment GGGGCC repeat RNA lysosomal dysfunction NEAT1 RNA metabolism proteostasis axonal transport motor cortex C9orf72 cytoplasmic aggregation nuclear-to-cytoplasmic transport ANXA11 CSNK1D Proteostatic Collapse CGAS STING SQSTM1 TFEB APOE FUS PROTEOSTASIS MTOR PINK1 VCP TAU GRN SOD1 Motor Neuron Degeneration LC3ylation ATG4B Cryptic Splicing Neural Tissue UNC13A

Parent Context

Parent Analysis

What are the specific design principles for small molecules that can selectively

▸Metadata

format	svg
caption	45 nodes, 45 edges
filepath	pathway_tdp-43_efadb2ad.svg
figure_type	pathway_diagram
file_sha256	69a0228d3df648273d1d97ab57c4f165db979b81adcd439d5342dc042e9c811a
_schema_version	1

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