Glioblastoma
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13
hypotheses
1
debates
0
challenges
0
pending proposals
🧠 Top Hypotheses
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0.78
· therapeutic
0.77
· therapeutic
SASP-Mediated Cholinergic Synapse Disruption
96% yes
💬 2
0.76
· mechanistic
0.72
· mechanistic
Mitochondrial Transfer Pathway Enhancement
79% yes
💬 2
0.70
· mechanistic
0.68
· mechanistic
Lipid Droplet Dynamics as Phenotype Switches
76% yes
💬 2
0.67
· mechanistic
0.67
· mechanistic
0.65
· therapeutic
0.64
· therapeutic
💬 Debates & Sessions
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The study demonstrates that high-neural glioblastoma cells form synapses with neurons both in vitro and in vivo, but the underlying molecular mechanis
gap_analysis · 2026-04-16
· score 0.6
🔍 Knowledge Gaps
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What determines the specificity of TGM2's dual binding to both SDC1 and LC3 during autophagosome-lysosome fusion?
neurodegeneration
How does the epigenetic neural signature mechanistically link to poor prognosis in glioblastoma patients?
neuro-oncology
Why do high-neural glioblastomas exhibit increased functional connectivity and what drives this phenomenon?
neuro-oncology
Why does CMA hyperactivation occur broadly across cancers despite tissue-specific contexts?
neurodegeneration
What is the mechanistic link between SMPD1 inhibition, ceramide depletion, and EGFR signaling disruption in GBM?
neuro-oncology
How does CMA-mediated TET3 degradation mechanistically silence the cGAS-STING pathway?
neuroinflammation
📋 Notebooks & Artifacts
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paper_figure · 2026-04-26
📄
figure · 2026-04-24
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