The abstract describes TGM2 simultaneously binding SDC1 and LC3 through LIRs to coordinate autophagosome-lysosome fusion, but the molecular determinants controlling this dual interaction remain unexplained. This mechanistic gap limits understanding of how to selectively disrupt this process. Gap type: unexplained_observation Source paper: SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes. (2023, Autophagy, PMID:35913916)
Landscape Summary: What determines the specificity of TGM2's dual binding to both SDC1 and LC3 during autophagosome-lysosome fusion? is a 0.79 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What determines the specificity of TGM2's dual binding to both SDC1 and LC3 during autophagosome-lysosome fusion? — INVOKE-2 (completed)
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