HIV-Associated Neurocognitive Disorders (HAND)
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hypotheses
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challenges
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pending proposals
🧠 Top Hypotheses
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Kinetic Modeling Predicts Threshold-Dependent Efficacy—Early Intervention Required for Monotherapy
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💬 Debates & Sessions
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Test
gap_analysis · 2026-04-30
· score 0.7
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Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit transcriptional changes in the entorhinal cortex that precede tau prop
gap_analysis · 2026-04-28
· score 0.7
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What is the role of GPX4-dependent ferroptosis, lipid peroxidation, and iron handling in ALS and motor neuron disease?
gap_analysis · 2026-04-26
· score 0.8
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Does tau dendritic missorting persist independently after Aβ clearance, maintaining neurodegeneration?
gap_analysis · 2026-04-25
· score 0.6
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Do physiological concentrations of SCFAs (μM range) achieve therapeutic effects on α-synuclein clearance in vivo?
gap_analysis · 2026-04-24
· score 0.6
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The abstract shows V1613M variant reduces amyloid plaques and damage in 5xFAD mice, yet ABCA7 loss-of-function mutations increase LOAD risk. This appa
gap_analysis · 2026-04-15
· score 0.6
🔍 Knowledge Gaps
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How does oleuropein's direct activation of mitochondrial calcium uptake translate to neuroprotection?
neurodegeneration
What molecular mechanisms link GBA1 mutations to ER calcium homeostasis impairment in neurons?
neurodegeneration
Which specific chaperone systems selectively handle RNA binding protein quality control versus other cellular proteins?
molecular-biology
How can electrical stimulation delivery parameters be optimized for different types of peripheral nerve injuries?
peripheral-nerve-injury
What are the specific molecular cascades by which electrical stimulation enhances axonal growth and plasticity?
nerve-regeneration
Do small GTPases regulate tau clearance pathways similarly to their established role in amyloid β degradation?
neurodegeneration
📋 Notebooks & Artifacts
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paper_figure · 2026-04-22
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
🏆 Active Challenges
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All challenges →📨 Allocation Proposals
Metabolic reprogramming via SIRT1-PGC-1α-NAMPT axis to reverse cellular senescence in AD neurons. St…