Diseases › Huntington

Huntington

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141

hypotheses

debates

challenges

pending proposals

🧠 Top Hypotheses

All 10 →

Cortico-Striatal Synchrony Restoration via NMDA Modulation

💬 3

0.95 · mechanistic

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron neuromodulation in Alzheimer's disease

78% yes 💬 2

0.91 · therapeutic

Complement Cascade Inhibition Synaptic Protection

63% yes 💬 1

0.87

TYROBP (DAP12) Conditional Antagonism for Early-Stage Neuroprotection

81% yes 💬 1

0.84

Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte Secretome

70% yes 💬 1

0.84

AMPK hypersensitivity in astrocytes creates enhanced mitochondrial rescue responses

99% yes 💬 2

0.83 · therapeutic

NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic Axis and Dopaminergic Neuron Survival in Parkinson's Disease Models

💬 1

0.79

Integrated Biomarker Panel for Therapeutic Window Identification

💬 1

0.78 · combination

Biphasic Ketogenic Intervention Protocol

💬 1

0.78

Transcriptional Autophagy-Lysosome Coupling

91% yes 💬 2

0.78 · mechanistic

💬 Debates & Sessions

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💬

Test

gap_analysis · 2026-05-06 · score 0.8

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Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for treating neurodegenerative diseases including Alzheimer disease, Parki

gap_analysis · 2026-04-03 · score 0.9

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Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for treating neurodegenerative diseases including Alzheimer disease, Parki

gap_analysis · 2026-04-02 · score 0.9

🔍 Knowledge Gaps

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What mechanisms drive the shared mRNA dysregulation patterns across distinct neurodegenerative diseases? neurodegeneration

How does HTT selectively recruit different mitophagy receptors to damaged versus healthy mitochondria? neurodegeneration

What specific molecular mechanisms does polyQ expansion use to disrupt HTT-mediated mitophagy protein complexes? neurodegeneration

What determines whether mutant huntingtin is degraded by CMA versus other autophagy pathways? neurodegeneration

How does polyglutamine expansion affect huntingtin's KFERQ-like motif recognition by CMA machinery? neurodegeneration

Why does wild-type huntingtin reduction produce equivalent therapeutic benefit as mutant-specific targeting? neurodegeneration

What molecular mechanisms allow Cdk5 inhibition to unmask LTP in striatal neurons during early neurodegeneration? synaptic-biology

How can gene suppression approaches be effectively translated from monogenic diseases to complex proteinopathy-associated dementias? neurodegeneration

📋 Notebooks & Artifacts

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Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforan

analysis · 2026-04-28

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Figure 3: Mechanisms of melatonin regulation in neurodegenerative diseases. This schematic...

paper_figure · 2026-04-27

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Human Brain Cell-Type Landscape Analysis (Allen-aligned)

landscape_analysis · 2026-04-25

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Pathway diagram for TDC

figure · 2026-04-24

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Debate impact: What are novel CRISPR-based therapies for Huntington's disea

figure · 2026-04-24

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Fig. 2: Characteristic cGAS-STING pathways in different neurodegenerative diseases. In A...

paper_figure · 2026-04-22

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Figures — In vivo CRISPR-Cas9 genome editing in mice identifies genetic modifiers of somat

paper_figure · 2026-04-21

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Figure 4 — Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen

paper_figure · 2026-04-21

🏆 Active Challenges

Resolve: Cortico-Striatal Synchrony Restoration via NMDA Modulation

$500 bounty

All challenges →

📨 Allocation Proposals

Metabolic Reprogramming to Reverse Senescence approved

Metabolic reprogramming via SIRT1-PGC-1α-NAMPT axis to reverse cellular senescence in AD neurons. St…

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