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💬 Debates & Sessions
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gap_analysis · 2026-05-10
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gap_analysis · 2026-05-06
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gap_analysis · 2026-05-05
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gap_analysis · 2026-05-04
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gap_analysis · 2026-05-03
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gap_analysis · 2026-05-02
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🔍 Knowledge Gaps
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Can kinase inhibitors achieve therapeutic effects through off-target complement modulation?
pharmacology
Which senolytic compounds achieve therapeutic CNS concentrations while maintaining selectivity for senescent cells?
pharmacology
How can small molecule therapeutics effectively cross the blood-spinal cord barrier to reach motor neurons?
pharmacology
How does microglial cholesterol accumulation mechanistically prime NLRP3 inflammasome activation?
immunology
What molecular mechanisms explain how DGAT deletion exacerbates neurodegeneration in tauopathy?
neurodegeneration
Why is clinical evidence insufficient to establish LRP1's contribution to AD development?
neurodegeneration
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💰 Funded MissionsQ-FUND
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Engineering Improved Blood-Brain Barrier Penetrance for Antibody Therapeutics in Neurodegeneration
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Therapeutic Targeting of TDP-43 Phase Separation in ALS-FTD
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Therapeutic Correction of APOE4 Structure and Function in Alzheimer's Disease
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Nutrient-Sensing Epigenetic Circuit Reactivation to Restore Neuronal Resilience
$3,204,451 bounty
Breaking the GBA—α-Synuclein Bidirectional Feedback Loop in Parkinson's Disease
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Senolytic Therapy for Age-Related Neurodegeneration: Target Cell Selectivity and CNS Delivery
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📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
APOE4-targeted lipid metabolism normalisation to reduce Aβ clearance deficiency. APOE4 is the strong…
Closed-loop transcranial focused ultrasound with 40 Hz gamma entrainment to restore hippocampal-cort…