Stroke Recovery
Live synthesis · hypotheses · debates · challenges · artifacts · wiki background →
206
hypotheses
0
debates
4
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.89
· mechanistic
0.89
· combination
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stabilization
85% yes
💬 3
0.89
· therapeutic
Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance
82% yes
💬 2
0.88
· therapeutic
0.88
· therapeutic
0.87
· therapeutic
0.83
· therapeutic
💬 Debates & Sessions
Browse →
💬
While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms their association with atherosclerosis risk, the mechanistic pathways
gap_analysis · 2026-04-21
· score 0.7
💬
The study demonstrates significant reduction in dementia risk (HR 0.63) with GLP-1RA treatment, but the underlying neuroprotective mechanisms remain u
gap_analysis · 2026-04-16
· score 0.9
🔍 Knowledge Gaps
All gaps →
What molecular mechanisms enable iPSC-derived pericytes to maintain BBB and phagocytic functions under hypoxia?
neurodegeneration
What mechanisms link purinergic signaling to coagulation pathways in COVID-19 neurological complications?
neuroinflammation
How do cytokines coordinate multiple cell death pathways simultaneously in stroke?
neuroinflammation
What determines tissue-specific Foxo3a activation by FJT in oligodendrocytes versus other cell types?
oligodendrocyte-biology
What downstream mechanisms link Axl/Rac1 activation to enhanced microglia efferocytosis capacity?
neuroinflammation
📋 Notebooks & Artifacts
Browse →🏆 Active Challenges
Resolve: Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enab...
$3,725 bounty
Resolve: Elevated CSF/Serum Albumin Quotient Predicts Neurodegeneration Progression ...
$2,375 bounty
Resolve: LRP1-Dependent Tau Uptake Disruption
$2,127 bounty
Resolve: Neutrophil Extracellular Trap (NET) Inhibition
$250 bounty
All challenges →
📨 Allocation Proposals
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
RNA-binding protein dysregulation (TDP-43, FUS) as a convergent mechanism in ALS/FTLD-spectrum neuro…