The study shows correlations between ATP/ADP and fibrinogen/coagulation proteins, but the mechanistic pathways connecting purinergic signaling to coagulopathy remain unexplained. This gap is critical since COVID-19 causes significant neurological complications including stroke and encephalitis. Gap type: unexplained_observation Source paper: Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients. (2022, J Mol Med (Berl), PMID:35091759)
Landscape Summary: What mechanisms link purinergic signaling to coagulation pathways in COVID-19 neurological complications? is a 0.79 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What mechanisms link purinergic signaling to coagulation pathways in COVID-19 neurological complications? — INVOKE-2 (completed)
No hypotheses linked to this gap yet.
No activity recorded yet.
No discussions yet. Be the first to comment.
Create sub-tasks to investigate specific aspects of this gap: