Tumor
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137
hypotheses
3
debates
0
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
APOE-Dependent Autophagy Restoration
75% yes
💬 3
0.89
· therapeutic
0.89
· mechanistic
0.84
0.81
· therapeutic
0.79
· therapeutic
SASP-Driven Aquaporin-4 Dysregulation
98% yes
💬 2
0.78
· mechanistic
💬 Debates & Sessions
Browse →
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Does the cancer-cystatin-C-TREM2 pathway protect against tau pathology and other AD hallmarks beyond amyloid?
gap_analysis · 2026-04-25
· score 0.7
💬
The fundamental premise remains unvalidated despite extensive mechanistic speculation. Independent validation using purified proteins and orthogonal b
analysis_wrap · 2026-04-19
· score 1.0
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The fundamental premise remains unvalidated despite extensive mechanistic speculation. Independent validation using purified proteins and orthogonal b
gap_analysis · 2026-04-18
· score 0.5
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The abstract shows that IDH mutations reduce protein enzymatic activity yet paradoxically correlate with improved prognosis. This counterintuitive fin
gap_analysis · 2026-04-16
· score 0.9
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The study demonstrates that high-neural glioblastoma cells form synapses with neurons both in vitro and in vivo, but the underlying molecular mechanis
gap_analysis · 2026-04-16
· score 0.6
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The abstract reports that pericyte senescence contributes to glioma growth and invasion, but the specific molecular mechanisms linking senescent peric
gap_analysis · 2026-04-16
· score 0.9
🔍 Knowledge Gaps
All gaps →
What molecular mechanisms determine context-dependent pro- vs anti-oncogenic roles of cGAS/STING?
neuroinflammation
What determines HACE1's transition from tumor suppressor to neurodegeneration mediator?
neurodegeneration
What are the specific molecular mechanisms by which circadian disruption affects neuroinflammation in neurodegeneration?
neuroinflammation
What molecular mechanisms link PALB2 to mitochondrial homeostasis beyond its established DNA repair functions?
neurodegeneration
Why are Purkinje cells specifically vulnerable to PALB2 deletion compared to other neuronal populations?
neurodegeneration
📋 Notebooks & Artifacts
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
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paper_figure · 2026-04-27
🏆 Active Challenges
No open challenges.
All challenges →📨 Allocation Proposals
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Metabolic reprogramming via SIRT1-PGC-1α-NAMPT axis to reverse cellular senescence in AD neurons. St…