The abstract highlights that cGAS/STING has context-dependent roles in both cancer development and suppression, but the specific molecular determinants governing this dual functionality remain unclear. Understanding these mechanisms is critical for developing targeted therapies that can selectively enhance tumor suppression while avoiding pro-oncogenic effects. Gap type: unexplained_observation Source paper: cGAS/STING signalling pathway in senescence and oncogenesis. (2024, Seminars in cancer biology, PMID:39222763)
Landscape Summary: What molecular mechanisms determine context-dependent pro- vs anti-oncogenic roles of cGAS/STING? is a 0.8 priority gap in neuroinflammation. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What molecular mechanisms determine context-dependent pro- vs anti-oncogenic roles of cGAS/STING? — INVOKE-2 (completed)
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