Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Α-SYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| microglial cell | stimulates | cell_type | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| S-equol-induced ferroptosis mechanism in TNBC cells | exploratory | Triple negative breast cancer | 0.900 | 0.00 | TNBC cell lines | proposed | N/A |
| Gandouling protection against brain injury in Wilson's disease via SIR | validation | Hepatolenticular degeneration | 0.900 | 0.00 | TX mice (Wilson's disease mode | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] | Yang M, Bian F, Feng X, Li L, Huang H et | Mol Ther | 2026 | 0 |
| Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] | Liu J, Cai X, Lin J, Zhang Z, Zhou Q et | Cell | 2026 | 0 |
| Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] | Gromadzka G, Tarnacka B, Cieślik M | Int J Mol Sci | 2026 | 0 |
| Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] | Tuo QZ, Bush AI, Lei P | Mol Psychiatry | 2026 | 0 |
| Fin(e)-tuning ferroptosis. [PMID:41576911] | Szylo KJ, Dixon SJ | Mol Cell | 2026 | 0 |
| GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] | Liu G, Wang Y, Huang H, Wang J, Yang J e | Cell Mol Immunol | 2026 | 0 |
| A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] | Xia Z, Yang X, Samovich SN, Tyurina YY, | Cell | 2026 | 0 |
| The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] | Park WH | Pharmacol Res | 2026 | 0 |
| Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] | Song C, Liu Z, Tang J, Huang Y | Neuropsychiatr Dis Treat | 2026 | 0 |
| Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] | Chen X | Trends Mol Med | 2026 | 0 |
| Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836] | Vinutha AS, Akshay S, Sree Agash SG, Cha | Archives of microbiology | 2026 | 0 |
| Montelukast Modulates MPTP-induced Ferroptosis and Neuroinflammation Linked To t [PMID:41712018] | ["Jung Yu Jin", "Choi Hyunsu", "Lee Seon | Neuromolecular medicine | 2026 | 0 |
| The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877] | Gurnani B, Jain N | The Journal of biological chem | 2026 | 0 |
| A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis. [PMID:41349546] | Lorenz SM, Wahida A, Bostock MJ, Seibt T | Cell | 2026 | 0 |
| Hypoxia-inducible factor-1 as targets for neuroprotection : from ferroptosis to [PMID:39466326] | ["Changyong Wang", "Shanyu Lv", "Hongyan | Neurological sciences : offici | 2025 | 0 |
| Gentiopicroside Attenuated Dopaminergic Neurodegeneration via Inhibiting Neuroin [PMID:40256942] | Unknown | Basic & clinical pharmacol | 2025 | 0 |
| Astragenol alleviates neuroinflammation and improves Parkinson's symptoms throug [PMID:40306495] | ["Shengnan Xiao", "Lianmei Liu", "Xuemei | Journal of ethnopharmacology | 2025 | 0 |
| Schisanhenol Inhibits MPTP/MPP<sup>+</sup>-Induced Ferroptosis in Dopaminergic N [PMID:41460594] | Unknown | Neurochemical research | 2025 | 0 |
| Carvedilol Confers Neuroprotective Activity Through Modulating Ferroptosis Key P [PMID:41243756] | Unknown | Journal of biochemical and mol | 2025 | 0 |
| Betulinic acid protects SH-SY5Y cells exposed to lipopolysaccharide and ferrous [PMID:40985323] | Pandey SK, Singh H, Ahmad S, Singh RK | Free radical research | 2025 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Α-SYN in their description or question text
Score: 0.620 · neurodegeneration · 2026-04-26
LRRK2 G2019S gain-of-function mutation hyperactivates kinase activity, dysregulating RAB GTPases and impairing lysosomal
Score: 0.605 · neurodegeneration · 2026-04-26
c-Abl (ABL1) phosphorylates α-synuclein at Y39, promoting aggregation and neuronal toxicity. Nilotinib (FDA-approved for
Score: 0.595 · neurodegeneration · 2026-04-26
Misfolded α-synuclein aggregates are transmitted via exosomes from donor to recipient neurons, templating endogenous aSy
Score: 0.580 · neurodegeneration · 2026-04-28
Forced nuclear localization of TFEB using AAV9-TFEB(S211A) induces transcription of autophagy-lysosomal genes, enhancing
Score: 0.580 · neurodegeneration · 2026-04-26
c-Abl kinase is activated in PD substantia nigra and phosphorylates parkin at Tyr143, inhibiting its E3 ligase activity
Score: 0.559 · neurodegeneration · 2026-04-18
## Mechanistic Overview AMPK Activation to Restore Autophagy and Clear α-Synuclein Aggregates starts from the claim that
Score: 0.540 · neurodegeneration · 2026-04-26
Commensal bacteria (E. coli, Salmonella) produce curli amyloid fibers encoded by the csg operon, while Candida and Sacch
Score: 0.533 · neurodegeneration · 2026-04-02
Dysbiotic bacteria compromise intestinal barrier integrity through zonulin pathway activation, allowing bacterial antige
Score: 0.511 · neurodegeneration · 2026-04-02
Specific gut bacterial strains produce short-chain fatty acids (SCFAs) that cross the blood-brain barrier and directly m
Score: 0.440 · neurodegeneration · 2026-04-26
Enteric α-synuclein misfolding spreads retrogradely via vagal afferents to DMV, then progressively to SNc (Braak stages
Score: 0.429 · neurodegeneration · 2026-04-18
## Mechanistic Overview GSK3β Inhibition to Prevent α-Synuclein Phosphorylation and Aggregation starts from the claim th