Gut Barrier Permeability-α-Synuclein Axis Modulation

graph TD
    A["Dysbiotic Bacteria<br/>E. coli, gram-negative"]
    B["LPS Endotoxin<br/>Release"]
    C["TLR4 Activation<br/>Inflammatory Signaling"]
    D["MLCK Activation<br/>Phosphorylation"]
    E["Tight Junction<br/>Disruption"]
    F["CLDN1, OCLN, ZO1<br/>Downregulation"]
    G["Gut Barrier<br/>Permeability"]
    H["alpha-Synuclein<br/>Aggregation"]
    I["Vagal Nerve<br/>Transmission"]
    J["CNS alpha-Synuclein<br/>Propagation"]
    K["Neurodegeneration<br/>Progression"]
    L["Tight Junction<br/>Stabilizers"]
    M["Probiotic<br/>Intervention"]

    A -->|"produces"| B
    B -->|"binds"| C
    C -->|"activates"| D
    D -->|"phosphorylates"| E
    E -->|"reduces"| F
    F -->|"increases"| G
    G -->|"promotes"| H
    H -->|"travels via"| I
    I -->|"spreads"| J
    J -->|"causes"| K
    L -->|"stabilizes"| F
    M -->|"restores"| A

    style A fill:#ef5350,color:#0d0d1a
    style B fill:#ef5350,color:#0d0d1a
    style C fill:#ef5350,color:#0d0d1a
    style D fill:#ef5350,color:#0d0d1a
    style E fill:#ef5350,color:#0d0d1a
    style F fill:#ce93d8,color:#0d0d1a
    style G fill:#ef5350,color:#0d0d1a
    style H fill:#ef5350,color:#0d0d1a
    style I fill:#4fc3f7,color:#0d0d1a
    style J fill:#ef5350,color:#0d0d1a
    style K fill:#ffd54f,color:#0d0d1a
    style L fill:#81c784,color:#0d0d1a
    style M fill:#81c784,color:#0d0d1a