Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Α-SYNUCLEIN PATHOLOGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| DOPAMINERGIC NEURONS IN SUBSTANTIA NIGRA | associated_with | cell_type | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C3/C3aR Pathway | modulates | pathway | 0.90 |
| 41390672 | were reduced in relation to | paper | 0.90 |
| Microglia Depletion | protects_against | mechanism | 0.88 |
| LAG3 | suppresses | protein | 0.85 |
| GLUCOSYLCERAMIDASE | regulates | enzyme | 0.85 |
| Csf Ddc | correlates_with | biomarker | 0.82 |
| GSK3Β | modulates | protein | 0.80 |
| CNTNAP4 | exacerbates | gene | 0.80 |
| VPS35 D620N | causes | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Α-SYNUCLEIN PATHOLOGY in their description or question text
No additional research found