protein

LAG3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

Summary

Page for LAG3 Protein (CD223)

View on Wiki →

🔬 Protein Info

Gene Symbol	LAG3
Aliases	CD223
Protein Type	Receptor
Function	LAG3 is primarily expressed on activated T cells, regulatory T cells (Tregs), natural killer cells, and to a lesser extent on B cells and dendritic cells.
Molecular Weight	57 kDa
Pathways	Alpha-Synuclein Transmission
UniProt ID	[P18627](https://www.uniprot.org/uniprotkb/P18627)
GeneCards	LAG3
Human Protein Atlas	LAG3
Approach	Mechanism
Blocking antibodies	Prevent fibril binding/uptake
Soluble LAG3	Decoy receptor for fibrils
Small molecule inhibitors	Block LAG3-fibril interaction
MHC Class II	Physiological
Alpha-synuclein fibrils	Pathological
Associated Diseases	Cancer, MICROGLIAL ACTIVATION, Parkinson's Disease
Interactions	APLP1, FOXP3, PI3K, RICTOR, MYC, RAGE
KG Connections	121 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LAG3(["LAG3"])
    alpha_synuclein["alpha-synuclein"]
    Co_inhibitory_Gene_Module["Co-inhibitory Gene Module"]
    APLP1["APLP1"]
    Alpha_Synuclein["Alpha-Synuclein"]
    Alpha_Synuclein_Transmission["Alpha-Synuclein Transmission"]
    Neurodegeneration["Neurodegeneration"]
    Parkinson["Parkinson"]
    PARKINSON["PARKINSON"]
    Dopaminergic["Dopaminergic"]
    Neuron["Neuron"]
    FOXP3["FOXP3"]
    RNA["RNA"]
    PI3K["PI3K"]
    RICTOR["RICTOR"]
    AMYLOID["AMYLOID"]
    LDHA["LDHA"]
    MYC["MYC"]
    neurodegeneration["neurodegeneration"]
    LAG3 <-->|"interacts"| alpha_synuclein
    LAG3 -->|"component_of"| Co_inhibitory_Gene_Module
    APLP1 <-->|"interacts"| LAG3
    LAG3 -->|"binds"| Alpha_Synuclein
    LAG3 -->|"involved in"| Alpha_Synuclein_Transmission
    LAG3 -->|"activates"| Neurodegeneration
    LAG3 -->|"therapeutic_tar"| Parkinson
    LAG3 -->|"therapeutic_tar"| PARKINSON
    LAG3 <-->|"interacts"| APLP1
    LAG3 -->|"activates"| Dopaminergic
    LAG3 -->|"activates"| Neuron
    LAG3 -.->|"inhibits"| FOXP3
    LAG3 -.-|"associated"| RNA
    LAG3 -.->|"inhibits"| PI3K
    LAG3 -.->|"inhibits"| RICTOR
    AMYLOID <-->|"interacts"| LAG3
    LDHA -.->|"inhibits"| LAG3
    MYC -.->|"inhibits"| LAG3
    LAG3 -->|"implicated_in"| neurodegeneration
    style LAG3 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (98)

Target	Relation	Type	Str
SNCA	binds	protein	0.95
alpha-synuclein	interacts_with	protein	0.95
microglial activation	mediates	process	0.92
Parkinson's Disease	therapeutic_target	disease	0.91
Alpha-Synuclein Transmission	involved_in	process	0.90
α-synuclein	facilitates_transmission_of	protein	0.90
Alpha-Synuclein Internalization	mediates	process	0.90
neuroinflammation	drives	process	0.90
A1 astrocyte	associated_with	cell_type	0.90
Alpha-Synuclein	binds	protein	0.90
alpha-synuclein	facilitates	protein	0.90
microglia	expressed_in	cell_type	0.90
Parkinson's Disease	implicated_in	disease	0.90
Parkinson'S Disease	therapeutic_target	disease	0.90
proinflammatory cytokines	upregulates	pathway	0.89
substantia nigra dopaminergic neurons	protects_against	cell_type	0.86
Dopaminergic Neurodegeneration	contributes_to	phenotype	0.85
α-synuclein pathology	suppresses	phenotype	0.85
co-inhibitory gene module	expressed_in	pathway	0.85
dopaminergic neuron	suppresses	cell_type	0.85
proinflammatory cytokine	associated_with	process	0.85
α-synucleinopathy	therapeutic_target	disease	0.85
microgliosis	suppresses	process	0.84
PI3K-Akt-Rictor pathway	inhibits	pathway	0.80
PI3K-Akt-Rictor	inhibits	pathway	0.70
MYC	interacts_with	gene	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	associated_with	disease	0.65
NEURODEGENERATION	protects_against	phenotype	0.65
NEURODEGENERATION	inhibits	phenotype	0.65
NEURODEGENERATION	targets	phenotype	0.65
LACTATE	inhibits	phenotype	0.65
ASTROCYTES	activates	cell_type	0.65
ASTROCYTES	causes	cell_type	0.65
GLIOSIS	regulates	phenotype	0.65
MICROGLIAL ACTIVATION	causes	phenotype	0.65
MICROGLIA	regulates	cell_type	0.65
APLP1	interacts_with	gene	0.60
FOXP3	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
RICTOR	inhibits	gene	0.60
MYC	inhibits	gene	0.60
TGFB1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
CD163	associated_with	gene	0.60
STAT5B	associated_with	gene	0.60
Il-6	associated_with	protein	0.60

Incoming (23)

Source	Relation	Type	Str
APLP1	interacts_with	protein	0.95
microglia	expressed_in	cell_type	0.94
SNCA	interacts_with	protein	0.93
AKT	activates	gene	0.65
MYC	inhibits	gene	0.60
AKT	inhibits	gene	0.60
FOXP3	inhibits	gene	0.60
TAU	inhibits	gene	0.60
MS4A4A	associated_with	gene	0.60
CCR8	associated_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
LDHA	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
GENES	associated_with	gene	0.60
RICTOR	activates	gene	0.50
aplp1	interacts_with	gene	0.50
aplp1	activates	gene	0.50
Neurodegeneration	activates	disease	0.50
Pi3K	activates	pathway	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
PARKINSON'S DISEASE	associated_with	disease	0.45
PARKINSON	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LAG3

Understanding Entity Pages

Summary

Wiki Pages (12)

LAG3 Protein (CD223)

Synuclein Pathway in Parkinson's Disease

Alpha-Synuclein Seeding Kinetics

Neuroinflammation in PD

Alpha-Synuclein Exosomal Secretion

Glial Cytoplasmic Inclusions in Multiple System Atrophy

Substantia Nigra Dopaminergic Neurons

Alpha-Synuclein Neuronal Uptake

Syndecan-3 Protein (SDC3)

APLP1 Gene