gene

CNTNAP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTNAP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

50Outgoing

16Incoming

Summary

CNTNAP4 is a gene implicated in neurodegeneration research. Key relationships include: causes, associated with, activates. Associated with Autism, PD, Parkinson. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CNTNAP4
Aliases	CASPR4, PALS, NTNG2-associated protein
Chromosome	16q23.3
Protein Type	Neurexin family cell adhesion molecule
Function	is a member of the neurexin family of transmembrane adhesion proteins.
Primary Expression	Brain (cortex, hippocampus, cerebellum), spinal cord
Pathways	Complement, SNCA Pathology
UniProt ID	Q9C0A0
NCBI Gene ID	12925
Ensembl ID	ENSG00000171804
OMIM	610610
GeneCards	CNTNAP4
Human Protein Atlas	CNTNAP4
Gene Name	Contactin-Associated Protein 4
Protein Class	Neurexin family cell adhesion molecule
Associated Diseases	Autism, PD, Parkinson
Interactions	Rb, NEURON, C1Q, MICROGLIA
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNTNAP4 — AlphaFold Q9C0A0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CNTNAP4["<b>CNTNAP4</b>"]
    Autism{"Autism"}
    CNTNAP4 -->|"associated with"| Autism
    Parkinson{"Parkinson"}
    CNTNAP4 -->|"activates"| Parkinson
    CNTNAP4 -->|"associated with"| Parkinson
    CNTNAP4 -->|"causes"| Parkinson
    ALPHA_SYNUCLEIN["ALPHA_SYNUCLEIN"]
    CNTNAP4 -->|"regulates"| ALPHA_SYNUCLEIN
    Complement(["Complement"])
    CNTNAP4 -->|"activates"| Complement
    CNTNAP4 -->|"associated with"| Complement
    CYTOKINES["CYTOKINES"]
    CNTNAP4 -->|"causes"| CYTOKINES
    CNTNAP4 -->|"causes"| Complement
    PD{"PD"}
    CNTNAP4 -->|"associated with"| PD
    Microglia["Microglia"]
    CNTNAP4 -->|"expressed in"| Microglia
    Astrocyte["Astrocyte"]
    CNTNAP4 -->|"expressed in"| Astrocyte
    C1Q["C1Q"]
    C1Q -->|"activates"| CNTNAP4
    C1Q -->|"associated with"| CNTNAP4
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"causes"| CNTNAP4
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"causes"| CNTNAP4
    C1Q -->|"causes"| CNTNAP4
    NEURON["NEURON"]
    NEURON -->|"activates"| CNTNAP4
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"protects against"| CNTNAP4
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"associated with"| CNTNAP4
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"causes"| CNTNAP4
    PARKINSON["PARKINSON"]
    PARKINSON -->|"causes"| CNTNAP4
    AND["AND"]
    AND -->|"regulates"| CNTNAP4
    CYTOKINES -->|"causes"| CNTNAP4
    style CNTNAP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

Target	Relation	Type	Str
SNCA Pathology	regulates	process	0.90
α-synuclein pathology	exacerbates	process	0.80
nigrostriatal DA neuron degeneration	exacerbates	process	0.80
ASTROCYTE	interacts_with	cell_type	0.80
Autism	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Parkinson	causes	disease	0.65
Parkinson	contributes_to	disease	0.65
ALPHA_SYNUCLEIN	regulates	protein	0.64
C1Q	causes	gene	0.60
Rb	activates	protein	0.60
Complement	activates	pathway	0.60
Complement	associated_with	pathway	0.60
CYTOKINES	causes	gene	0.60
Complement	causes	pathway	0.60
ASTROCYTE	associated_with	gene	0.60
COMPLEMENT	causes	gene	0.60
PARKINSON	causes	gene	0.60
AND	regulates	gene	0.60
ASTROCYTES	causes	gene	0.60
NEURON	activates	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
MICROGLIA	protects_against	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
Dopaminergic	causes	cell_type	0.60
Microglia	therapeutic_target	cell_type	0.60
Neuron	activates	cell_type	0.60
Astrocyte	associated_with	cell_type	0.60
PARKINSON	contributes_to	gene	0.60
CYTOKINES	contributes_to	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
COMPLEMENT	contributes_to	gene	0.60
Microglia	inhibits	cell_type	0.60
Astrocyte	contributes_to	cell_type	0.60
Dopaminergic	contributes_to	cell_type	0.60
Α-Synuclein	therapeutic_target	protein	0.60
Cytokine	contributes_to	protein	0.60
PD	associated_with	disease	0.56
Microglia	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50
SYNUCLEIN	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
SYNUCLEIN	protects_against	concept	0.50
α-SYNUCLEIN	protects_against	concept	0.50
SYNUCLEIN	regulates	concept	0.50
α-SYNUCLEIN	regulates	concept	0.50

Incoming (16)

Source	Relation	Type	Str
C1Q	activates	gene	0.60
C1Q	associated_with	gene	0.60
C1Q	causes	gene	0.60
C1Q	contributes_to	gene	0.60
COMPLEMENT	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	protects_against	gene	0.60
ASTROCYTE	associated_with	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
PARKINSON	causes	gene	0.60
CYTOKINES	causes	gene	0.60
AUTISM	associated_with	entity	0.60
MICROGLIA	inhibits	gene	0.60
microglia	associated_with	cell_type	0.50
microglia	protects_against	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found