Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Aβ toxicity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondrial bioenergetic failure | causes | process | 0.70 |
| mitochondrial dysfunction | causes | mechanism | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| dendritic tau | required_for | protein | 0.90 |
| tau | regulates | protein | 0.90 |
| 32429102 | induces | paper | 0.90 |
| 32429102 | leads to | paper | 0.90 |
| p38γ | modulates | enzyme | 0.85 |
| COG133 | protective_against | peptide | 0.70 |
| APOE4 | associated_with | protein | 0.70 |
| Fyn activation | mediates | pathway | 0.70 |
| NPY co-release | regulates | phenotype | 0.70 |
| JNK3 | mediates | gene | 0.70 |
| caspase-12 | mediates | protein | 0.70 |
| TFEB overexpression | inhibits | phenotype | 0.70 |
| COG133 | reduces | peptide | 0.70 |
| 32456156 | aim to rescue | paper | 0.60 |
| 34239348 | mediates | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Neuropeptide Y (NPY) Co-release from PV Interneurons Modulat | 0.560 | Alzheimer's disease | Closed-loop optogenetic targeting PV int |
Scientific analyses that reference this entity
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.700
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.740
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.865
proteomics | 2026-04-16 | 19 hypotheses Top: 0.591
neurodegeneration | 2026-04-14 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.72 · 2026-04-28
closed · Rounds: 4 · Score: 0.65 · 2026-04-25
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-20
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
Hypotheses and analyses mentioning Aβ toxicity in their description or question text
No additional research found