TAU

Understanding Entity Pages

This page aggregates everything SciDEX knows about TAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Microtubule-associated protein tau (MAPT) stabilizes neuronal microtubules. Hyperphosphorylation causes detachment and aggregation into neurofibrillary tangles, a hallmark of Alzheimer disease and other tauopathies. Pathological tau spreads trans-synaptically and drives neuronal dysfunction.

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graph TD
    subgraph Pathology["Pathology"]
        TAU["TAU"] -->|"associated with"| NEURODEGENERATION["NEURODEGENERATION"]
        TAU["TAU"] -->|"associated with"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
        TAU["TAU"] -->|"associated with"| TAUOPATHY["TAUOPATHY"]
        TAU["TAU"] -->|"associated with"| Alzheimer_2["Alzheimer"]
        AMYLOID["AMYLOID"] -->|"associated with"| TAU["TAU"]
        MICROGLIA["MICROGLIA"] -->|"associated with"| TAU["TAU"]
        NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated with"| TAU["TAU"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| TAU["TAU"]
        APP["APP"] -->|"associated with"| TAU["TAU"]
        ALS["ALS"] -->|"associated with"| TAU["TAU"]
    end
    subgraph Signaling["Signaling"]
        TAU["TAU"] -->|"activates"| NEURODEGENERATION_1["NEURODEGENERATION"]
        TAU["TAU"] -->|"activates"| Alzheimer["Alzheimer"]
        TAU["TAU"] -->|"activates"| Als["Als"]
        TAU["TAU"] -->|"activates"| Autophagy["Autophagy"]
        TAU["TAU"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    end
    style TAU fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style NEURODEGENERATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEURODEGENERATION_1 fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TAUOPATHY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AMYLOID fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style NEUROINFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0