gene

JNK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JNK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

1Analyses

39Outgoing

21Incoming

0Experiments

1Debates

Summary

JNK3 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with Neurodegeneration. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JNK3
Aliases	MAPK10, c-Jun N-terminal Kinase 3
Function	is a neuron-specific member of the MAPK family that plays critical roles in neuronal survival, stress responses, and synaptic plasticity.
Primary Expression	brain regions vulnerable to neurodegeneration:
Molecular Weight	46 kDa
Amino Acids	464 aa
Pathways	MAPK
Ensembl ID	ENSG00000109339
GeneCards	JNK3
Human Protein Atlas	JNK3
Associated Diseases	neurodegeneration
Interactions	amyloid_beta, AND, APOPTOSIS, ASTROCYTE, ASTROCYTES, FERROPTOSIS
KG Connections	60 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JNK3["JNK3"]
    AND["AND"]
    JNK3 -->|"activates"| AND
    Ferroptosis(["Ferroptosis"])
    JNK3 -->|"activates"| Ferroptosis
    Apoptosis(["Apoptosis"])
    JNK3 -->|"activates"| Apoptosis
    Mapk(["Mapk"])
    JNK3 -->|"activates"| Mapk
    neurodegeneration["neurodegeneration"]
    JNK3 -->|"implicated in"| neurodegeneration
    JNK["JNK"]
    JNK -->|"activates"| JNK3
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| JNK3
    MAPK10["MAPK10"]
    MAPK10 -->|"activates"| JNK3
    GENES["GENES"]
    GENES -->|"activates"| JNK3
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"activates"| JNK3
    style JNK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
excitotoxicity	causes	mechanism	0.70
Aβ Toxicity	mediates	phenotype	0.70
Neurodegeneration	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Stroke	activates	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Parkinson	contributes_to	disease	0.65
Oxidative Stress	contributes_to	pathway	0.60
Apoptosis	expressed_in	pathway	0.60
MYELIN	activates	gene	0.60
Ubiquitin-Proteasome	therapeutic_target	pathway	0.60
ALZHEIMER	contributes_to	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
C-JUN	therapeutic_target	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
Proteasome	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
JNK	therapeutic_target	gene	0.60
JUN	associated_with	gene	0.60
LRP2	activates	gene	0.60
JNK1	expressed_in	gene	0.60
JUN	therapeutic_target	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
JNK2	expressed_in	gene	0.60
Alzheimer's disease	inhibits	disease	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
Apoptosis	activates	pathway	0.60
Mapk	activates	pathway	0.60
PARP1	inhibits	gene	0.60
MAPK signaling	participates_in	pathway	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
PI3K	inhibits	gene	0.60
Ferroptosis	activates	pathway	0.60

Incoming (21)

Source	Relation	Type	Str
amyloid_beta	activates	protein	0.70
JNK	therapeutic_target	gene	0.60
ASTROCYTES	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
STROKE	activates	gene	0.60
PERK	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	contributes_to	gene	0.60
ATP	therapeutic_target	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
JNK	activates	gene	0.60
MAPK10	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
GENES	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
C-JUN	associated_with	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
GSK3	inhibits	gene	0.60
AND	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract claims Cdk5 activation is the primary cause of AD, contradicting th

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning JNK3 in their description or question text

No additional research found