Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALS-FTD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Loss Of TDP-43 Splicing Repression | associated_with | mechanism | 0.95 |
| TDP-43 | associated_with | protein | 0.95 |
| TARDBP | associated_with | protein | 0.95 |
| Cryptic HDGFL2 | biomarker_for | biomarker | 0.93 |
| C9ORF72 | risk_factor_for | gene | 0.92 |
| Cytoplasmic TDP-43 Aggregation | causes | mechanism | 0.90 |
| Impaired Cryptic Exon Repression | biomarker_for | biomarker | 0.80 |
| TDP-43 | implicated_in | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Stathmin-2 Splice Switching to Prevent Axonal Degeneration A | 0.664 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||