gene

FUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2332Connections

4Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

FUS is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with AD, ALI, ALS. Connected to 507 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FUS
Full Name	FUS (Fused in Sarcoma)
Chromosome	16p11.2.
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	cytoplasm, FUS undergoes progressive oligomerization through weak multivalent interactions. Phosphorylation, SUMOylation
Pathways	Blood-Brain Barrier, Hippo Pathway, Oxidative Stress, Sod1, Tdp-43
UniProt ID	Search UniProt
GeneCards	FUS
Human Protein Atlas	FUS
Associated Diseases	AD, ALI, ALS, AMI, Aging
Known Drugs/Compounds	RNA oligonucleotides, Rna Oligonucleotides, Antisense Oligonucleotide, ADUCANUMAB
Interactions	TARDBP, LC3, ACTB, G3BP1, BCL2, C9ORF72
SciDEX Hypotheses	ASO-Mediated Exon Skipping to Restore FUS-TAZ Chap
KG Connections	1482 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: FUS — PDB 4FDD Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

FUS (Redirect)

redirect · 681 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

flowchart TD
    FUS(["FUS"])
    TARDBP(["TARDBP"])
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ALS(["ALS"])
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    Als["Als"]
    SOD1(["SOD1"])
    MECP2(["MECP2"])
    GENES(["GENES"])

    FUS -->|"associated with"| TARDBP
    FUS -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    ALS -->|"associated with"| FUS
    FUS -->|"risk factor for"| Amyotrophic_Lateral_Sclerosis
    FUS -->|"associated with"| AMYOTROPHIC_LATERAL_SCLEROSIS
    FUS -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    FUS -->|"associated with"| Als
    FUS -->|"causes"| Amyotrophic_Lateral_Sclerosis
    FUS -->|"associated with"| SOD1
    FUS -->|"regulates"| MECP2
    FUS -->|"interacts with"| ALS
    FUS -->|"activates"| ALS
    FUS -->|"associated with"| GENES
    FUS -->|"associated with"| ALS
    FUS -->|"interacts with"| AMYOTROPHIC_LATERAL_SCLEROSIS

    style FUS fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1201)

Target	Relation	Type	Str
TARDBP	associated_with	gene	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
DEMENTIA	associated_with	disease	0.98
TDP-43	interacts_with	gene	0.95
Stress Granule Transcriptome	modulates	phenotype	0.95
Phase Transition	involved_in	process	0.95
liquid phase condensation	involved_in	process	0.95
Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.95
ALS	involved_in	disease	0.95
FTD	involved_in	disease	0.95
Neurodegeneration	involved_in	process	0.95
Early-Onset ALS	risk_factor_for	phenotype	0.93
TAU	associated_with	gene	0.90
Motor Neuron Degeneration	causes	disease	0.90
Ftld-Fet	component_of	disease	0.90
circEHD2	regulates	gene	0.90
Stress Granules	interacts_with	process	0.90
HSPA8 mRNA Dendritic Localization	regulates	process	0.90
Histone H1.2	interacts_with	protein	0.90
Cytoplasmic Mislocalization	associated_with	phenotype	0.90
Pathological Aggregation	associated_with	phenotype	0.90
Motor Neuron Degeneration	contributes_to	process	0.90
Neuromuscular Synapses	regulates	phenotype	0.90
HSPA8	regulates	gene	0.90
Stress Granules	associated_with	process	0.90
H1F2	interacts_with	protein	0.90
Fibrillization	involved_in	process	0.90
biomolecular condensates	component_of	mechanism	0.90
pathological aggregation	involved_in	process	0.90
Nuclear Localization	involved_in	process	0.90
Cytoplasmic Accumulation	involved_in	process	0.90
motor neuron death	contributes_to	process	0.90
NEURON	associated_with	gene	0.90
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
ALS	risk_factor_for	disease	0.90
Proteostasis	regulates	process	0.90
frontotemporal dementia	associated_with	disease	0.90
oxidative stress response	participates_in	pathway	0.90
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.90
cytoplasmic mislocalization	involved_in	process	0.88
Glucose Oxidation	regulates	process	0.85
PARylation	involved_in	process	0.85
Motor Neuron Degeneration	involved_in	process	0.85
Myogenesis	regulates	process	0.85
Rna-Binding Proteins	interacts_with	protein	0.85
Mrna Transport	modulates	process	0.85
Parylation	involved_in	process	0.85
Pathological Changes	contributes_to	phenotype	0.85
RNA metabolism	regulates	process	0.85

Incoming (1131)

Source	Relation	Type	Str
ALS	associated_with	disease	1.00
RNA oligonucleotides	binds	compound	0.90
Rna Oligonucleotides	interacts_with	compound	0.90
Rna Oligonucleotides	inhibits	compound	0.90
Mistranslation	exacerbates	process	0.85
RNA oligonucleotides	targets	compound	0.85
KAPB2	interacts_with	protein	0.85
DIPEPTIDE REPEAT PROTEINS	interacts_with	protein	0.85
ALS	interacts_with	entity	0.82
Stress Granules	mediates	process	0.80
Chronological Ageing	modulates	process	0.80
Antisense Oligonucleotide	therapeutic_target	drug	0.80
ALS	modulates	gene	0.80
ALS	accumulates_in	gene	0.80
DNA	disrupts	gene	0.80
MATR3	interacts_with	protein	0.75
ALS	activates	disease	0.74
ALZHEIMER'S DISEASE	associated_with	disease	0.72
C9ORF72	interacts_with	gene	0.70
C9ORF72	contributes_to	gene	0.70
GAIN	causes	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
DNA	causes	gene	0.70
DNA	accumulates_in	gene	0.70
TDP-43	phosphorylates	gene	0.65
UBIQUITIN	recruits	protein	0.65
ALZHEIMER	associated_with	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.65
CORTEX	regulates	brain_region	0.65
FRONTAL	regulates	brain_region	0.65
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.65
CORTEX	transports	brain_region	0.65
ACTB	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
SMCR8	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
TOLLIP	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
C9ORF72	inhibits	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
C1Q	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ASO-Mediated Exon Skipping to Restore FUS-TAZ Chaperone Axis	0.606	neurodegeneration	How does FUS loss-of-function in TAZ reg
Optogenetic viral vector delivery via tFUS-mediated blood-br	0.557	Alzheimer's disease	Circuit-level neural dynamics in neurode
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m	0.348	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745]	Rydzanicz M, Jagła M, Kosinska J, Tomasi	Clin Genet	2017	1
TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375]	van Spronsen M, Mikhaylova M, Lipka J, S	Neuron	2013	1
Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670]	Randall TS, Moores C, Stephenson FA	FEBS Lett	2013	1
Therapeutic developments in pancreatic cancer. [PMID:37798442]	["Hu Z", "O'Reilly E"]	Nature reviews. Gastroenterolo	2024	0
Defining treatment-resistant depression. [PMID:31638723]	["Gaynes B", "Lux L", "Gartlehner G", "A	Depression and anxiety	2020	0
Emerging trends in global freshwater availability. [PMID:29769728]	["Rodell M", "Famiglietti J", "Wiese D",	Nature	2018	0
Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969]	["Kurmani S", "Squire I"]	Current heart failure reports	2017	0
Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335]	["Aquino R", "Vasques P", "Cavalcante D"	Revista do Colegio Brasileiro	2017	0
The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062]	["Kane J", "Johnson R", "Robinson C", "J	The Journal of adolescent heal	2016	0
A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607]	["Naqvi N", "Li M", "Calvert J", "Tejada	Cell	2014	0
Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899]	["Pivac N", "Knezevi\u0107 A", "Gornik O	Molecular & cellular proteomic	2011	0
The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503]	["Bulgakova N", "Knust E"]	Journal of cell science	2009	0
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423]	["Landsman L", "Bar-On L", "Zernecke A",	Blood	2009	0
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324]	Brickley K, Smith MJ, Beck M, Stephenson	The Journal of biological chem	2005	0

FUS

Understanding Entity Pages

Summary

Wiki Pages (21)

FUS (Redirect)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Novel Therapy Index

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

Pathway Diagram

Outgoing (1201)

Incoming (1131)

Targeting Hypotheses (4)

Mentioning Analyses (5)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

Human connectome alterations and network-level dysfunction in Alzheimer disease

RNA binding protein dysregulation across ALS FTD and AD

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (14)

FUS

Understanding Entity Pages

Summary

Wiki Pages (21)

FUS (Redirect)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Novel Therapy Index

Device Therapies Comparison for CBS/PSP

calcium-dysregulation-comparison

nimodipine-als

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

Frontotemporal Dementia (FTD)

HNRNPA2B1 Protein

ALS Failed Approaches Analysis

Autophagy Mechanisms

oxidative-stress-comparison

ftd-tdp-pathology

amyloid-beta-metalloproteinases

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

rankings

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

TRA2B Protein - Transformer-2 Beta

Pathway Diagram

Outgoing (1201)

Incoming (1131)

Targeting Hypotheses (4)

Mentioning Analyses (5)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

Human connectome alterations and network-level dysfunction in Alzheimer disease

RNA binding protein dysregulation across ALS FTD and AD

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (14)