protein

ALSINPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about ALSINPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Alsin, encoded by the ALS2 gene (also known as ALS2), is a Rab5-specific guanine nucleotide exchange factor (GEF) that plays critical roles in endosomal trafficking, neuronal survival, and axonal maintenance[@hadano2006].

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🔬 Protein Info

Gene Symbol	ALSINPROTEIN
Full Name	Alsin
Protein Type	Protein
Function	is a Rab5-specific guanine nucleotide exchange factor (GEF) that plays critical roles in endosomal trafficking, neuronal survival, and axonal maintenance[@hadano2006].
Primary Expression	the central nervous system, with highest levels in motor neurons, pyramidal neurons, and cerebellar Purkinje cells[@ito2007]
Subcellular Localization	to the cytoplasm and associated with endosomal membranes, where it regulates the
Molecular Weight	210 kDa
Amino Acids	847 aa
UniProt ID	Search UniProt
GeneCards	ALSINPROTEIN
Human Protein Atlas	ALSINPROTEIN
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections	19 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ALSINPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Alsin Protein

protein · 1791 words

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Pathway Diagram

graph TD
    ALSINPROTEIN["ALSINPROTEIN"]
    neurodegeneration["neurodegeneration"]
    ALSINPROTEIN -->|"implicated_in"| neurodegeneration
    style ALSINPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning ALSINPROTEIN in their description or question text

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