protein

ALSINPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALSINPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Alsin, encoded by the ALS2 gene (also known as ALS2), is a Rab5-specific guanine nucleotide exchange factor (GEF) that plays critical roles in endosomal trafficking, neuronal survival, and axonal maintenance[@hadano2006].

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🔬 Protein Info

Gene Symbol	ALSIN
Full Name	Alsin
Aliases	ALS2/Alsin
Chromosome	2q33.
Protein Type	Gene
Function	Alsin is a multiunctional protein with several key cellular roles:
Subcellular Localization	the cytoplasm and associated with endosomal membranes, where it regulates the fusion and movement of early endosomes thr
Molecular Weight	210 kDa
Amino Acids	847 aa
UniProt ID	Search UniProt
GeneCards	ALSIN
Human Protein Atlas	ALSIN
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections	19 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ALSINPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Alsin Protein

protein · 1791 words

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Pathway Diagram

graph TD
    ALSINPROTEIN["ALSINPROTEIN"]
    neurodegeneration["neurodegeneration"]
    ALSINPROTEIN -->|"implicated_in"| neurodegeneration
    style ALSINPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found