protein

AMYLOIDBETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOIDBETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Amyloid-beta (Aβ) peptides are cleavage products of amyloid precursor protein (APP). Oligomeric and fibrillar Aβ42 aggregates form extracellular plaques in Alzheimer disease, triggering synaptic dysfunction, neuroinflammation, and tau pathology. Central target for AD therapeutics.

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🔬 Protein Info

Gene Symbol	APP
Aliases	AMYLOIDBETA
Chromosome	21
Protein Family	Amyloid precursor protein family
Function	is a 40-42 amino acid peptide that plays a central role in the pathogenesis of Alzheimer's disease (AD) and related amyloidopathies[@hardy2002].
Primary Expression	Extracellular, membrane-associated
UniProt ID	P05067
GeneCards	APP
Human Protein Atlas	APP
Associated Diseases	Alzheimer's Disease, Cerebral Amyloid Angiopathy
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: AMYLOIDBETA — AlphaFold P05067 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Amyloid-Beta (Aβ)

protein · 3168 words

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Pathway Diagram

graph TD
    APP["Amyloid Precursor Protein (APP)"]
    BACE1["BACE1"]
    GAMMASEC["gamma-secretase"]
    AB["Amyloid Beta (Abeta)"]
    AB4240["Abeta40/42 peptides"]
    OLIGOMERS["Abeta oligomers"]
    PLAQUES["Amyloid plaques"]
    TAU["Tau protein"]
    NFTS["Neurofibrillary tangles"]
    NEUROINFLAM["Neuroinflammation"]
    OXIDATIVE["Oxidative stress"]
    NEURONDEATH["Neuronal death"]
    ALZHEIMER["Alzheimer's disease"]
    NEPRILYSIN["Neprilysin"]
    IDE["Insulin-degrading enzyme"]

    APP -->|"cleaved by"| BACE1
    BACE1 -->|"produces"| AB4240
    APP -->|"cleaved by"| GAMMASEC
    GAMMASEC -->|"produces"| AB4240
    AB4240 -->|"aggregates into"| AB
    AB -->|"forms"| OLIGOMERS
    AB -->|"deposits as"| PLAQUES
    OLIGOMERS -->|"triggers"| TAU
    TAU -->|"forms"| NFTS
    AB -->|"induces"| NEUROINFLAM
    AB -->|"causes"| OXIDATIVE
    OLIGOMERS -->|"leads to"| NEURONDEATH
    NEURONDEATH -->|"results in"| ALZHEIMER
    NEPRILYSIN -->|"degrades"| AB
    IDE -->|"degrades"| AB

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class AB central
    class OLIGOMERS,PLAQUES,NFTS,NEUROINFLAM,OXIDATIVE,NEURONDEATH pathological
    class NEPRILYSIN,IDE protective
    class APP,BACE1,GAMMASEC,TAU regulatory
    class ALZHEIMER disease

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning AMYLOIDBETA in their description or question text

No additional research found