Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ano10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ANO10 |
| Full Name | Anoctamin 10 |
| Aliases | Anoctamin 10 (TMEM16J |
| Chromosome | 3p21.31 |
| Protein Family | Anoctamin/TMEM16 |
| Protein Type | Channel |
| Function | ANO10 encodes a calcium-activated chloride channel (CaCC) that regulates chloride ion flux across cell membranes. |
| Primary Expression | various tissues, including the brain, endocrine glands, and peripheral tissues |
| GeneCards | ANO10 |
| Human Protein Atlas | ANO10 |
| Calcium activation | ANO10 is activated by intracellular calcium ions, opening the chloride channel [@huang2013] |
| Tissue distribution | Expressed in brain, thyroid, adrenal gland, pancreas, and testis [@framework] |
| Membrane topology | Ten transmembrane domains with intracellular N- and C-termini [@pedemonte2014] |
| Drug development | Small molecule modulators of ANO10 could potentially regulate neuronal excitability [@hartzell2020] |
| Biomarker research | ANO10 expression patterns might serve as biomarkers for certain neurodegenerative conditions [@mohler2018] |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["ano10 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ANO10 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ANO10 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ano10 in their description or question text
No additional research found