| Gene Symbol | ANO10 |
| Full Name | Anoctamin 10 |
| Aliases | Anoctamin 10 (TMEM16J |
| Chromosome | 3p21.31 |
| Protein Family | Anoctamin/TMEM16 |
| Protein Type | Channel |
| Function | ANO10 encodes a calcium-activated chloride channel (CaCC) that regulates chloride ion flux across cell membranes. |
| Primary Expression | various tissues, including the brain, endocrine glands, and peripheral tissues |
| GeneCards | ANO10 |
| Human Protein Atlas | ANO10 |
| Calcium activation | ANO10 is activated by intracellular calcium ions, opening the chloride channel [@huang2013] |
| Tissue distribution | Expressed in brain, thyroid, adrenal gland, pancreas, and testis [@framework] |
| Membrane topology | Ten transmembrane domains with intracellular N- and C-termini [@pedemonte2014] |
| Drug development | Small molecule modulators of ANO10 could potentially regulate neuronal excitability [@hartzell2020] |
| Biomarker research | ANO10 expression patterns might serve as biomarkers for certain neurodegenerative conditions [@mohler2018] |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!